Contraindications Do not administer OPV to any person with immunosuppression or to any household member of immunodeficient person. This includes combined immunodeficiency, hypogammaglobulinemia, agammaglobulinemia, thymic abnormalities, leukemia, lymphoma, generalized malignancy, lowered resistance to infection from therapy with corticosteroids, alkylating drugs, antimetabolites, or radiation. Advise vaccine recipients to avoid contact with such persons for at least 6 to 8 wk. Do not give OPV to member of household in which there is family history of immunodeficiency until immune status of intended recipient and other children in family is determined to be normal. IPV is preferred for immunizing all persons in these circumstances.

 

Route/Dosage

OLDER CHILDREN, ADOLESCENTS & ADULTS: PO 0.5 ml. Give 2 doses no < 6 wk apart (or no > 8 wk apart) followed by third dose 6 to 12 mo later. INFANTS: PO 0.5 ml. Administer at 2, 4, and 15 to 18 mo. A fourth dose is given when child begins school if third dose of primary series was administered before child’s fourth birthday. OPV may be administered with any of following: Distilled water, chlorinated tap water, simple syrup, milk, bread, sugar cube, or cake.

 

Interactions Immune globulin (IG) does not interfere with immunity following OPV. However, do not administer OPV < 7 days after IG administration unless unavoidable, such as unexpected travel to or contact with epidemic or endemic areas or persons. If OPV is given within 1 wk after IG, the OPV dose should probably be repeated 3 mo later, if immunity is still needed. Like all live viral vaccines, administration to patients or contacts of patients receiving immunosuppressant drugs, including steroids or radiation may predispose patients to disseminated infections or insufficient response to immunization. They may remain susceptible despite immunization. Several routine pediatric vaccines may safely and effectively be administered simultaneously at separate injection sites (eg, DTP, MMR, IPV, Hib, hepatitis B, influenza). National authorities recommend simultaneous immunization at separate sites as indicated by age or health risk. Live virus vaccines may cause delayed-hypersensitivity skin test results (eg, tuberculin, histoplasmin) to appear falsely negative. Effect may persist for several weeks after vaccination. Give tuberculin tests either prior to live-virus vaccination, simultaneously with it, or ³ 6 wk after vaccination.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

OTHER: Vaccine-associated paralysis occurs with frequency of 1 case per 2.6 million OPV vaccine doses distributed.

 

Precautions

Do not use OPV in immunodeficient persons, including persons with congenital or acquired immune deficiencies, whether due to genetics, disease or drug, or radiation therapy. Contains live viruses. Avoid use in HIV-positive persons, regardless of whether symptomatic or asymptomatic. Poliovirus is shed for 6 to 8 wk in vaccinees’ stool and by pharyngeal route. Pregnancy: Category C. Use OPV in pregnancy if exposure is imminent and immediate protection is needed. Lactation: Breastfeeding does not generally interfere with successful immunization of infants, despite IgA antibody secretion in breast milk.

PATIENT CARE CONSIDERATIONS

 

Administration/Storage

• Give medication orally.
• Administer directly or mix with distilled water, plain tap water, syrup, milk, or sugar cube. Changes in color of product are of no significance as long as product remains clear.
• Store in freezer. Drug may remain in liquid state to –14°C (7°F) because of sorbitol content.
• If frozen, vaccine must be thawed completely before use.
• Follow recommended schedule for immunization (2, 4, 15 or 18 mo and at 4 to 6 yr).
• Discard poliovirus pipettes in manner that will inactivate live virus (eg, autoclave, incinerator).
• Maximum of 10 freeze-thaw cycles are permitted provided (1) temperature dose not exceed 8° C (46° F) and (2) vaccine remains thawed for no more than 24 hr total.

 

Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Note if patient has had hypersensitivity test within 48 hr. Live virus could cause false-negative result.
• Document manufacturer, lot number, date of administration, name, address, and title of person administering on patient’s chart.
• Adhere to guidelines of Vaccine Adverse Event Reporting System for reporting adverse effects (800–822–7967).

 

Patient/Family Education

• Advise women to abstain from breastfeeding 2 to 3 hr before and after vaccination of infants to permit establishment of viruses in gut.
• Explain risks and benefits of vaccination. Point out to parents or patient that vaccine produces protective antibodies against poliomyelitis.
• Tell parents that child should receive dose at 2, 4, and 15 or 18 mo and at 4 to 6 yr to be fully immunized.
• Explain that attenuated live virus vaccine may be shed for a few weeks following vaccination. This virus is not harmful to normal individuals but may cause disease in immunocompromised patients. Therefore vaccine recipient must stay away from immunocompromised individuals.

Indications for Drugs ::

(POE-lee-oh-VYE-russ vaccine)

Orimune

Class: Vaccine, live virus

 

Action Induces protective antibodies, reducing intestinal and pharyngeal excretion of poliovirus. OPV administration simulates natural infection, inducing active mucosal and systemic immunity against poliovirus types 1, 2, and 3.

 

Indications Prevention of poliomyelitis. Infants as young as 6 to 12 wk and all unimmunized children and adolescents up to 18 yr are usual candidates for routine OPV prophylaxis. OPV is also recommended for control of epidemic poliomyelitis. If < 4 wk remain before protection is needed, single dose of OPV is recommended, with remaining vaccine doses given later if person remains at increased risk. Immunization with IPV may be indicated for unimmunized parents and those in other special situations in which protection may be needed. In household with immunocompromised member or other close contacts or in household with unimmunized adult, use only IPV for all those requiring poliovirus immunization.

Adults: Primary immunization with inactivated polio vaccine is recommended whenever feasible for unimmunized adults subject to increased risk of exposure, such as by travel to or contact with epidemic or endemic areas (eg, developing countries) and for those employed in medical and sanitation facilities.

 

Contraindications Do not administer OPV to any person with immunosuppression or to any household member of immunodeficient person. This includes combined immunodeficiency, hypogammaglobulinemia, agammaglobulinemia, thymic abnormalities, leukemia, lymphoma, generalized malignancy, lowered resistance to infection from therapy with corticosteroids, alkylating drugs, antimetabolites, or radiation. Advise vaccine recipients to avoid contact with such persons for at least 6 to 8 wk. Do not give OPV to member of household in which there is family history of immunodeficiency until immune status of intended recipient and other children in family is determined to be normal. IPV is preferred for immunizing all persons in these circumstances.

 

Route/Dosage

OLDER CHILDREN, ADOLESCENTS & ADULTS: PO 0.5 ml. Give 2 doses no < 6 wk apart (or no > 8 wk apart) followed by third dose 6 to 12 mo later. INFANTS: PO 0.5 ml. Administer at 2, 4, and 15 to 18 mo. A fourth dose is given when child begins school if third dose of primary series was administered before child’s fourth birthday. OPV may be administered with any of following: Distilled water, chlorinated tap water, simple syrup, milk, bread, sugar cube, or cake.

 

Interactions Immune globulin (IG) does not interfere with immunity following OPV. However, do not administer OPV < 7 days after IG administration unless unavoidable, such as unexpected travel to or contact with epidemic or endemic areas or persons. If OPV is given within 1 wk after IG, the OPV dose should probably be repeated 3 mo later, if immunity is still needed. Like all live viral vaccines, administration to patients or contacts of patients receiving immunosuppressant drugs, including steroids or radiation may predispose patients to disseminated infections or insufficient response to immunization. They may remain susceptible despite immunization. Several routine pediatric vaccines may safely and effectively be administered simultaneously at separate injection sites (eg, DTP, MMR, IPV, Hib, hepatitis B, influenza). National authorities recommend simultaneous immunization at separate sites as indicated by age or health risk. Live virus vaccines may cause delayed-hypersensitivity skin test results (eg, tuberculin, histoplasmin) to appear falsely negative. Effect may persist for several weeks after vaccination. Give tuberculin tests either prior to live-virus vaccination, simultaneously with it, or ³ 6 wk after vaccination.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

OTHER: Vaccine-associated paralysis occurs with frequency of 1 case per 2.6 million OPV vaccine doses distributed.

 

Precautions

Do not use OPV in immunodeficient persons, including persons with congenital or acquired immune deficiencies, whether due to genetics, disease or drug, or radiation therapy. Contains live viruses. Avoid use in HIV-positive persons, regardless of whether symptomatic or asymptomatic. Poliovirus is shed for 6 to 8 wk in vaccinees’ stool and by pharyngeal route. Pregnancy: Category C. Use OPV in pregnancy if exposure is imminent and immediate protection is needed. Lactation: Breastfeeding does not generally interfere with successful immunization of infants, despite IgA antibody secretion in breast milk.

PATIENT CARE CONSIDERATIONS

 

Administration/Storage

• Give medication orally.
• Administer directly or mix with distilled water, plain tap water, syrup, milk, or sugar cube. Changes in color of product are of no significance as long as product remains clear.
• Store in freezer. Drug may remain in liquid state to –14°C (7°F) because of sorbitol content.
• If frozen, vaccine must be thawed completely before use.
• Follow recommended schedule for immunization (2, 4, 15 or 18 mo and at 4 to 6 yr).
• Discard poliovirus pipettes in manner that will inactivate live virus (eg, autoclave, incinerator).
• Maximum of 10 freeze-thaw cycles are permitted provided (1) temperature dose not exceed 8° C (46° F) and (2) vaccine remains thawed for no more than 24 hr total.

 

Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Note if patient has had hypersensitivity test within 48 hr. Live virus could cause false-negative result.
• Document manufacturer, lot number, date of administration, name, address, and title of person administering on patient’s chart.
• Adhere to guidelines of Vaccine Adverse Event Reporting System for reporting adverse effects (800–822–7967).

 

Patient/Family Education

• Advise women to abstain from breastfeeding 2 to 3 hr before and after vaccination of infants to permit establishment of viruses in gut.
• Explain risks and benefits of vaccination. Point out to parents or patient that vaccine produces protective antibodies against poliomyelitis.
• Tell parents that child should receive dose at 2, 4, and 15 or 18 mo and at 4 to 6 yr to be fully immunized.
• Explain that attenuated live virus vaccine may be shed for a few weeks following vaccination. This virus is not harmful to normal individuals but may cause disease in immunocompromised patients. Therefore vaccine recipient must stay away from immunocompromised individuals.

Drug Dose ::

(POE-lee-oh-VYE-russ vaccine)

Orimune

Class: Vaccine, live virus

 

Action Induces protective antibodies, reducing intestinal and pharyngeal excretion of poliovirus. OPV administration simulates natural infection, inducing active mucosal and systemic immunity against poliovirus types 1, 2, and 3.

 

Indications Prevention of poliomyelitis. Infants as young as 6 to 12 wk and all unimmunized children and adolescents up to 18 yr are usual candidates for routine OPV prophylaxis. OPV is also recommended for control of epidemic poliomyelitis. If < 4 wk remain before protection is needed, single dose of OPV is recommended, with remaining vaccine doses given later if person remains at increased risk. Immunization with IPV may be indicated for unimmunized parents and those in other special situations in which protection may be needed. In household with immunocompromised member or other close contacts or in household with unimmunized adult, use only IPV for all those requiring poliovirus immunization.

Adults: Primary immunization with inactivated polio vaccine is recommended whenever feasible for unimmunized adults subject to increased risk of exposure, such as by travel to or contact with epidemic or endemic areas (eg, developing countries) and for those employed in medical and sanitation facilities.

 

Contraindications Do not administer OPV to any person with immunosuppression or to any household member of immunodeficient person. This includes combined immunodeficiency, hypogammaglobulinemia, agammaglobulinemia, thymic abnormalities, leukemia, lymphoma, generalized malignancy, lowered resistance to infection from therapy with corticosteroids, alkylating drugs, antimetabolites, or radiation. Advise vaccine recipients to avoid contact with such persons for at least 6 to 8 wk. Do not give OPV to member of household in which there is family history of immunodeficiency until immune status of intended recipient and other children in family is determined to be normal. IPV is preferred for immunizing all persons in these circumstances.

 

Route/Dosage

OLDER CHILDREN, ADOLESCENTS & ADULTS: PO 0.5 ml. Give 2 doses no < 6 wk apart (or no > 8 wk apart) followed by third dose 6 to 12 mo later. INFANTS: PO 0.5 ml. Administer at 2, 4, and 15 to 18 mo. A fourth dose is given when child begins school if third dose of primary series was administered before child’s fourth birthday. OPV may be administered with any of following: Distilled water, chlorinated tap water, simple syrup, milk, bread, sugar cube, or cake.

 

Interactions Immune globulin (IG) does not interfere with immunity following OPV. However, do not administer OPV < 7 days after IG administration unless unavoidable, such as unexpected travel to or contact with epidemic or endemic areas or persons. If OPV is given within 1 wk after IG, the OPV dose should probably be repeated 3 mo later, if immunity is still needed. Like all live viral vaccines, administration to patients or contacts of patients receiving immunosuppressant drugs, including steroids or radiation may predispose patients to disseminated infections or insufficient response to immunization. They may remain susceptible despite immunization. Several routine pediatric vaccines may safely and effectively be administered simultaneously at separate injection sites (eg, DTP, MMR, IPV, Hib, hepatitis B, influenza). National authorities recommend simultaneous immunization at separate sites as indicated by age or health risk. Live virus vaccines may cause delayed-hypersensitivity skin test results (eg, tuberculin, histoplasmin) to appear falsely negative. Effect may persist for several weeks after vaccination. Give tuberculin tests either prior to live-virus vaccination, simultaneously with it, or ³ 6 wk after vaccination.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

OTHER: Vaccine-associated paralysis occurs with frequency of 1 case per 2.6 million OPV vaccine doses distributed.

 

Precautions

Do not use OPV in immunodeficient persons, including persons with congenital or acquired immune deficiencies, whether due to genetics, disease or drug, or radiation therapy. Contains live viruses. Avoid use in HIV-positive persons, regardless of whether symptomatic or asymptomatic. Poliovirus is shed for 6 to 8 wk in vaccinees’ stool and by pharyngeal route. Pregnancy: Category C. Use OPV in pregnancy if exposure is imminent and immediate protection is needed. Lactation: Breastfeeding does not generally interfere with successful immunization of infants, despite IgA antibody secretion in breast milk.

PATIENT CARE CONSIDERATIONS

 

Administration/Storage

• Give medication orally.
• Administer directly or mix with distilled water, plain tap water, syrup, milk, or sugar cube. Changes in color of product are of no significance as long as product remains clear.
• Store in freezer. Drug may remain in liquid state to –14°C (7°F) because of sorbitol content.
• If frozen, vaccine must be thawed completely before use.
• Follow recommended schedule for immunization (2, 4, 15 or 18 mo and at 4 to 6 yr).
• Discard poliovirus pipettes in manner that will inactivate live virus (eg, autoclave, incinerator).
• Maximum of 10 freeze-thaw cycles are permitted provided (1) temperature dose not exceed 8° C (46° F) and (2) vaccine remains thawed for no more than 24 hr total.

 

Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Note if patient has had hypersensitivity test within 48 hr. Live virus could cause false-negative result.
• Document manufacturer, lot number, date of administration, name, address, and title of person administering on patient’s chart.
• Adhere to guidelines of Vaccine Adverse Event Reporting System for reporting adverse effects (800–822–7967).

 

Patient/Family Education

• Advise women to abstain from breastfeeding 2 to 3 hr before and after vaccination of infants to permit establishment of viruses in gut.
• Explain risks and benefits of vaccination. Point out to parents or patient that vaccine produces protective antibodies against poliomyelitis.
• Tell parents that child should receive dose at 2, 4, and 15 or 18 mo and at 4 to 6 yr to be fully immunized.
• Explain that attenuated live virus vaccine may be shed for a few weeks following vaccination. This virus is not harmful to normal individuals but may cause disease in immunocompromised patients. Therefore vaccine recipient must stay away from immunocompromised individuals.

Contraindication ::

(POE-lee-oh-VYE-russ vaccine)

Orimune

Class: Vaccine, live virus

 

Action Induces protective antibodies, reducing intestinal and pharyngeal excretion of poliovirus. OPV administration simulates natural infection, inducing active mucosal and systemic immunity against poliovirus types 1, 2, and 3.

 

Indications Prevention of poliomyelitis. Infants as young as 6 to 12 wk and all unimmunized children and adolescents up to 18 yr are usual candidates for routine OPV prophylaxis. OPV is also recommended for control of epidemic poliomyelitis. If < 4 wk remain before protection is needed, single dose of OPV is recommended, with remaining vaccine doses given later if person remains at increased risk. Immunization with IPV may be indicated for unimmunized parents and those in other special situations in which protection may be needed. In household with immunocompromised member or other close contacts or in household with unimmunized adult, use only IPV for all those requiring poliovirus immunization.

Adults: Primary immunization with inactivated polio vaccine is recommended whenever feasible for unimmunized adults subject to increased risk of exposure, such as by travel to or contact with epidemic or endemic areas (eg, developing countries) and for those employed in medical and sanitation facilities.

 

Contraindications Do not administer OPV to any person with immunosuppression or to any household member of immunodeficient person. This includes combined immunodeficiency, hypogammaglobulinemia, agammaglobulinemia, thymic abnormalities, leukemia, lymphoma, generalized malignancy, lowered resistance to infection from therapy with corticosteroids, alkylating drugs, antimetabolites, or radiation. Advise vaccine recipients to avoid contact with such persons for at least 6 to 8 wk. Do not give OPV to member of household in which there is family history of immunodeficiency until immune status of intended recipient and other children in family is determined to be normal. IPV is preferred for immunizing all persons in these circumstances.

 

Route/Dosage

OLDER CHILDREN, ADOLESCENTS & ADULTS: PO 0.5 ml. Give 2 doses no < 6 wk apart (or no > 8 wk apart) followed by third dose 6 to 12 mo later. INFANTS: PO 0.5 ml. Administer at 2, 4, and 15 to 18 mo. A fourth dose is given when child begins school if third dose of primary series was administered before child’s fourth birthday. OPV may be administered with any of following: Distilled water, chlorinated tap water, simple syrup, milk, bread, sugar cube, or cake.

 

Interactions Immune globulin (IG) does not interfere with immunity following OPV. However, do not administer OPV < 7 days after IG administration unless unavoidable, such as unexpected travel to or contact with epidemic or endemic areas or persons. If OPV is given within 1 wk after IG, the OPV dose should probably be repeated 3 mo later, if immunity is still needed. Like all live viral vaccines, administration to patients or contacts of patients receiving immunosuppressant drugs, including steroids or radiation may predispose patients to disseminated infections or insufficient response to immunization. They may remain susceptible despite immunization. Several routine pediatric vaccines may safely and effectively be administered simultaneously at separate injection sites (eg, DTP, MMR, IPV, Hib, hepatitis B, influenza). National authorities recommend simultaneous immunization at separate sites as indicated by age or health risk. Live virus vaccines may cause delayed-hypersensitivity skin test results (eg, tuberculin, histoplasmin) to appear falsely negative. Effect may persist for several weeks after vaccination. Give tuberculin tests either prior to live-virus vaccination, simultaneously with it, or ³ 6 wk after vaccination.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

OTHER: Vaccine-associated paralysis occurs with frequency of 1 case per 2.6 million OPV vaccine doses distributed.

 

Precautions

Do not use OPV in immunodeficient persons, including persons with congenital or acquired immune deficiencies, whether due to genetics, disease or drug, or radiation therapy. Contains live viruses. Avoid use in HIV-positive persons, regardless of whether symptomatic or asymptomatic. Poliovirus is shed for 6 to 8 wk in vaccinees’ stool and by pharyngeal route. Pregnancy: Category C. Use OPV in pregnancy if exposure is imminent and immediate protection is needed. Lactation: Breastfeeding does not generally interfere with successful immunization of infants, despite IgA antibody secretion in breast milk.

PATIENT CARE CONSIDERATIONS

 

Administration/Storage

• Give medication orally.
• Administer directly or mix with distilled water, plain tap water, syrup, milk, or sugar cube. Changes in color of product are of no significance as long as product remains clear.
• Store in freezer. Drug may remain in liquid state to –14°C (7°F) because of sorbitol content.
• If frozen, vaccine must be thawed completely before use.
• Follow recommended schedule for immunization (2, 4, 15 or 18 mo and at 4 to 6 yr).
• Discard poliovirus pipettes in manner that will inactivate live virus (eg, autoclave, incinerator).
• Maximum of 10 freeze-thaw cycles are permitted provided (1) temperature dose not exceed 8° C (46° F) and (2) vaccine remains thawed for no more than 24 hr total.

 

Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Note if patient has had hypersensitivity test within 48 hr. Live virus could cause false-negative result.
• Document manufacturer, lot number, date of administration, name, address, and title of person administering on patient’s chart.
• Adhere to guidelines of Vaccine Adverse Event Reporting System for reporting adverse effects (800–822–7967).

 

Patient/Family Education

• Advise women to abstain from breastfeeding 2 to 3 hr before and after vaccination of infants to permit establishment of viruses in gut.
• Explain risks and benefits of vaccination. Point out to parents or patient that vaccine produces protective antibodies against poliomyelitis.
• Tell parents that child should receive dose at 2, 4, and 15 or 18 mo and at 4 to 6 yr to be fully immunized.
• Explain that attenuated live virus vaccine may be shed for a few weeks following vaccination. This virus is not harmful to normal individuals but may cause disease in immunocompromised patients. Therefore vaccine recipient must stay away from immunocompromised individuals.

Drug Precautions ::

(POE-lee-oh-VYE-russ vaccine)

Orimune

Class: Vaccine, live virus

 

Action Induces protective antibodies, reducing intestinal and pharyngeal excretion of poliovirus. OPV administration simulates natural infection, inducing active mucosal and systemic immunity against poliovirus types 1, 2, and 3.

 

Indications Prevention of poliomyelitis. Infants as young as 6 to 12 wk and all unimmunized children and adolescents up to 18 yr are usual candidates for routine OPV prophylaxis. OPV is also recommended for control of epidemic poliomyelitis. If < 4 wk remain before protection is needed, single dose of OPV is recommended, with remaining vaccine doses given later if person remains at increased risk. Immunization with IPV may be indicated for unimmunized parents and those in other special situations in which protection may be needed. In household with immunocompromised member or other close contacts or in household with unimmunized adult, use only IPV for all those requiring poliovirus immunization.

Adults: Primary immunization with inactivated polio vaccine is recommended whenever feasible for unimmunized adults subject to increased risk of exposure, such as by travel to or contact with epidemic or endemic areas (eg, developing countries) and for those employed in medical and sanitation facilities.

 

Contraindications Do not administer OPV to any person with immunosuppression or to any household member of immunodeficient person. This includes combined immunodeficiency, hypogammaglobulinemia, agammaglobulinemia, thymic abnormalities, leukemia, lymphoma, generalized malignancy, lowered resistance to infection from therapy with corticosteroids, alkylating drugs, antimetabolites, or radiation. Advise vaccine recipients to avoid contact with such persons for at least 6 to 8 wk. Do not give OPV to member of household in which there is family history of immunodeficiency until immune status of intended recipient and other children in family is determined to be normal. IPV is preferred for immunizing all persons in these circumstances.

 

Route/Dosage

OLDER CHILDREN, ADOLESCENTS & ADULTS: PO 0.5 ml. Give 2 doses no < 6 wk apart (or no > 8 wk apart) followed by third dose 6 to 12 mo later. INFANTS: PO 0.5 ml. Administer at 2, 4, and 15 to 18 mo. A fourth dose is given when child begins school if third dose of primary series was administered before child’s fourth birthday. OPV may be administered with any of following: Distilled water, chlorinated tap water, simple syrup, milk, bread, sugar cube, or cake.

 

Interactions Immune globulin (IG) does not interfere with immunity following OPV. However, do not administer OPV < 7 days after IG administration unless unavoidable, such as unexpected travel to or contact with epidemic or endemic areas or persons. If OPV is given within 1 wk after IG, the OPV dose should probably be repeated 3 mo later, if immunity is still needed. Like all live viral vaccines, administration to patients or contacts of patients receiving immunosuppressant drugs, including steroids or radiation may predispose patients to disseminated infections or insufficient response to immunization. They may remain susceptible despite immunization. Several routine pediatric vaccines may safely and effectively be administered simultaneously at separate injection sites (eg, DTP, MMR, IPV, Hib, hepatitis B, influenza). National authorities recommend simultaneous immunization at separate sites as indicated by age or health risk. Live virus vaccines may cause delayed-hypersensitivity skin test results (eg, tuberculin, histoplasmin) to appear falsely negative. Effect may persist for several weeks after vaccination. Give tuberculin tests either prior to live-virus vaccination, simultaneously with it, or ³ 6 wk after vaccination.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

OTHER: Vaccine-associated paralysis occurs with frequency of 1 case per 2.6 million OPV vaccine doses distributed.

 

Precautions

Do not use OPV in immunodeficient persons, including persons with congenital or acquired immune deficiencies, whether due to genetics, disease or drug, or radiation therapy. Contains live viruses. Avoid use in HIV-positive persons, regardless of whether symptomatic or asymptomatic. Poliovirus is shed for 6 to 8 wk in vaccinees’ stool and by pharyngeal route. Pregnancy: Category C. Use OPV in pregnancy if exposure is imminent and immediate protection is needed. Lactation: Breastfeeding does not generally interfere with successful immunization of infants, despite IgA antibody secretion in breast milk.

PATIENT CARE CONSIDERATIONS

 

Administration/Storage

• Give medication orally.
• Administer directly or mix with distilled water, plain tap water, syrup, milk, or sugar cube. Changes in color of product are of no significance as long as product remains clear.
• Store in freezer. Drug may remain in liquid state to –14°C (7°F) because of sorbitol content.
• If frozen, vaccine must be thawed completely before use.
• Follow recommended schedule for immunization (2, 4, 15 or 18 mo and at 4 to 6 yr).
• Discard poliovirus pipettes in manner that will inactivate live virus (eg, autoclave, incinerator).
• Maximum of 10 freeze-thaw cycles are permitted provided (1) temperature dose not exceed 8° C (46° F) and (2) vaccine remains thawed for no more than 24 hr total.

 

Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Note if patient has had hypersensitivity test within 48 hr. Live virus could cause false-negative result.
• Document manufacturer, lot number, date of administration, name, address, and title of person administering on patient’s chart.
• Adhere to guidelines of Vaccine Adverse Event Reporting System for reporting adverse effects (800–822–7967).

 

Patient/Family Education

• Advise women to abstain from breastfeeding 2 to 3 hr before and after vaccination of infants to permit establishment of viruses in gut.
• Explain risks and benefits of vaccination. Point out to parents or patient that vaccine produces protective antibodies against poliomyelitis.
• Tell parents that child should receive dose at 2, 4, and 15 or 18 mo and at 4 to 6 yr to be fully immunized.
• Explain that attenuated live virus vaccine may be shed for a few weeks following vaccination. This virus is not harmful to normal individuals but may cause disease in immunocompromised patients. Therefore vaccine recipient must stay away from immunocompromised individuals.

Drug Side Effects ::

(POE-lee-oh-VYE-russ vaccine)

Orimune

Class: Vaccine, live virus

 

Action Induces protective antibodies, reducing intestinal and pharyngeal excretion of poliovirus. OPV administration simulates natural infection, inducing active mucosal and systemic immunity against poliovirus types 1, 2, and 3.

 

Indications Prevention of poliomyelitis. Infants as young as 6 to 12 wk and all unimmunized children and adolescents up to 18 yr are usual candidates for routine OPV prophylaxis. OPV is also recommended for control of epidemic poliomyelitis. If < 4 wk remain before protection is needed, single dose of OPV is recommended, with remaining vaccine doses given later if person remains at increased risk. Immunization with IPV may be indicated for unimmunized parents and those in other special situations in which protection may be needed. In household with immunocompromised member or other close contacts or in household with unimmunized adult, use only IPV for all those requiring poliovirus immunization.

Adults: Primary immunization with inactivated polio vaccine is recommended whenever feasible for unimmunized adults subject to increased risk of exposure, such as by travel to or contact with epidemic or endemic areas (eg, developing countries) and for those employed in medical and sanitation facilities.

 

Contraindications Do not administer OPV to any person with immunosuppression or to any household member of immunodeficient person. This includes combined immunodeficiency, hypogammaglobulinemia, agammaglobulinemia, thymic abnormalities, leukemia, lymphoma, generalized malignancy, lowered resistance to infection from therapy with corticosteroids, alkylating drugs, antimetabolites, or radiation. Advise vaccine recipients to avoid contact with such persons for at least 6 to 8 wk. Do not give OPV to member of household in which there is family history of immunodeficiency until immune status of intended recipient and other children in family is determined to be normal. IPV is preferred for immunizing all persons in these circumstances.

 

Route/Dosage

OLDER CHILDREN, ADOLESCENTS & ADULTS: PO 0.5 ml. Give 2 doses no < 6 wk apart (or no > 8 wk apart) followed by third dose 6 to 12 mo later. INFANTS: PO 0.5 ml. Administer at 2, 4, and 15 to 18 mo. A fourth dose is given when child begins school if third dose of primary series was administered before child’s fourth birthday. OPV may be administered with any of following: Distilled water, chlorinated tap water, simple syrup, milk, bread, sugar cube, or cake.

 

Interactions Immune globulin (IG) does not interfere with immunity following OPV. However, do not administer OPV < 7 days after IG administration unless unavoidable, such as unexpected travel to or contact with epidemic or endemic areas or persons. If OPV is given within 1 wk after IG, the OPV dose should probably be repeated 3 mo later, if immunity is still needed. Like all live viral vaccines, administration to patients or contacts of patients receiving immunosuppressant drugs, including steroids or radiation may predispose patients to disseminated infections or insufficient response to immunization. They may remain susceptible despite immunization. Several routine pediatric vaccines may safely and effectively be administered simultaneously at separate injection sites (eg, DTP, MMR, IPV, Hib, hepatitis B, influenza). National authorities recommend simultaneous immunization at separate sites as indicated by age or health risk. Live virus vaccines may cause delayed-hypersensitivity skin test results (eg, tuberculin, histoplasmin) to appear falsely negative. Effect may persist for several weeks after vaccination. Give tuberculin tests either prior to live-virus vaccination, simultaneously with it, or ³ 6 wk after vaccination.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

OTHER: Vaccine-associated paralysis occurs with frequency of 1 case per 2.6 million OPV vaccine doses distributed.

 

Precautions

Do not use OPV in immunodeficient persons, including persons with congenital or acquired immune deficiencies, whether due to genetics, disease or drug, or radiation therapy. Contains live viruses. Avoid use in HIV-positive persons, regardless of whether symptomatic or asymptomatic. Poliovirus is shed for 6 to 8 wk in vaccinees’ stool and by pharyngeal route. Pregnancy: Category C. Use OPV in pregnancy if exposure is imminent and immediate protection is needed. Lactation: Breastfeeding does not generally interfere with successful immunization of infants, despite IgA antibody secretion in breast milk.

PATIENT CARE CONSIDERATIONS

 

Administration/Storage

• Give medication orally.
• Administer directly or mix with distilled water, plain tap water, syrup, milk, or sugar cube. Changes in color of product are of no significance as long as product remains clear.
• Store in freezer. Drug may remain in liquid state to –14°C (7°F) because of sorbitol content.
• If frozen, vaccine must be thawed completely before use.
• Follow recommended schedule for immunization (2, 4, 15 or 18 mo and at 4 to 6 yr).
• Discard poliovirus pipettes in manner that will inactivate live virus (eg, autoclave, incinerator).
• Maximum of 10 freeze-thaw cycles are permitted provided (1) temperature dose not exceed 8° C (46° F) and (2) vaccine remains thawed for no more than 24 hr total.

 

Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Note if patient has had hypersensitivity test within 48 hr. Live virus could cause false-negative result.
• Document manufacturer, lot number, date of administration, name, address, and title of person administering on patient’s chart.
• Adhere to guidelines of Vaccine Adverse Event Reporting System for reporting adverse effects (800–822–7967).

 

Patient/Family Education

• Advise women to abstain from breastfeeding 2 to 3 hr before and after vaccination of infants to permit establishment of viruses in gut.
• Explain risks and benefits of vaccination. Point out to parents or patient that vaccine produces protective antibodies against poliomyelitis.
• Tell parents that child should receive dose at 2, 4, and 15 or 18 mo and at 4 to 6 yr to be fully immunized.
• Explain that attenuated live virus vaccine may be shed for a few weeks following vaccination. This virus is not harmful to normal individuals but may cause disease in immunocompromised patients. Therefore vaccine recipient must stay away from immunocompromised individuals.

Drug Mode of Action ::  

(POE-lee-oh-VYE-russ vaccine)

Orimune

Class: Vaccine, live virus

 

Action Induces protective antibodies, reducing intestinal and pharyngeal excretion of poliovirus. OPV administration simulates natural infection, inducing active mucosal and systemic immunity against poliovirus types 1, 2, and 3.