Details About Generic Salt ::  Selegili

Main Medicine Class:: Antiparkinson   

(seh-LEH-jih-leen HIGH-droe-KLOR-ide)

Carbex, Eldepryl, Selegiline HCl

Class: Antiparkinson

Drugs Class ::

 Action Selective type B monoamine oxidase (MAO) inhibitor thought to increase dopaminergic activity. MAO enzyme breaks down catecholamines and serotonin. Selegiline may also interfere with dopamine reuptake at synapse.

Indications for Drugs ::

 Indications Adjunct to levodopa/carbidopa in idiopathic Parkinson’s disease, postencephalic parkinsonism/symptomatic parkinsonism.

Drug Dose ::

 Route/Dosage

ADULTS: PO 10 mg/day as divided dose of 5 mg each taken at breakfast and lunch. Do not exceed 10 mg/day. After 2 to 3 days of treatment, try reducing levodopa/carbidopa dose by 10 to 30%. Further reductions may be possible during continued selegiline therapy.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Effects have not been evaluated. Maximum: Do not exceed recommended daily dose of 10 mg/day because of risks associated with nonselective inhibition of MAO (potentially serious food or drug interactions may occur at higher doses). Hypertensive crisis risk: Selegiline can be given with active amine-containing medications and tyramine foods as long as recommended dose is not exceeded. However, report any possible symptoms suggestive of hypertensive crisis.

Drug Side Effects ::

 Adverse Reactions

CV: Palpitations; orthostatic hypotension; arrhythmia; hypertension; new or increased angina; syncope. CNS: Dizziness; lightheadedness; fainting; confusion; hallucinations; vivid dreams; headache; anxiety; tension; insomnia; lethargy; depression; loss of balance; delusions; dyskinesias; increased akinetic involuntary movements; bradykinesia; chorea. DERM: Sweating; rash; photosensitivity. EENT: Diplopia; blurred vision. GI: Nausea; abdominal pain; dry mouth; diarrhea. GU: Sexual dysfunction; urinary retention, frequency, hesitancy. OTHER: Generalized ache; leg pain; low back pain; weight loss.

Drug Mode of Action ::  

 Action Selective type B monoamine oxidase (MAO) inhibitor thought to increase dopaminergic activity. MAO enzyme breaks down catecholamines and serotonin. Selegiline may also interfere with dopamine reuptake at synapse.

Drug Interactions ::

 Interactions

Fluoxetine: May produce a “serotonin” syndrome (CNS irritability, increased muscle tone, altered consciousness). Meperidine: Could result in agitation, seizures, diaphoresis and fever, which may progress to coma, apnea and death. Reactions may occur several wks following withdrawal of selegiline.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Monitor vital signs, especially BP and respirations.
• Assess patient for decrease in akathisia and mood.
• Assess patient’s mental status: affect, mood, behavioral changes, depression.
• Dosage of levodopa/carbidopa may be reduced after 2 to 3 days of treatment.
• Assess for side effects, particularly nausea, dizziness, lightheadedness, abdominal pain, confusion, hallucination.
• Assist patient with ambulation at beginning of therapy.
• Assess diet for tyramine-containing foods.
• Implement safety measures to prevent falls, especially during initial treatment.

Drug Storage/Management ::

 Administration/Storage

• Administer 5 mg with breakfast and with lunch.
• Do not exceed 10 mg daily.

Drug Notes ::

 Patient/Family Education

• Encourage patient to change position slowly to prevent orthostatic hypotension.
• Instruct patient to avoid driving or other potentially hazardous activities until effect of medication is determined.
• Explain that dosage of levodopa/carbidopa may be reduced after initiation of adjunctive therapy.
• Identify tyramine-containing foods; explain rationale for exclusion from diet.
• Instruct patient to report these side effects: twitching, eye spasms.
• Caution patient to use drug exactly as prescribed. Explain that if drug is discontinued, parkinsonian crisis may occur.
• Advise patient not to exceed 10 mg/day dose.
• Inform patient and family of symptoms of hypertensive crisis and when to call physician. Instruct them to report severe headache or other unusual symptoms.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.