Details About Generic Salt ::  Thiabend

Main Medicine Class:: Anti-infective,anthelmintic   

(THIGH-uh-BEND-uh-zole)

Mintezol

Class: Anti-infective/anthelmintic

Drugs Class ::

 Action Inhibits helminth-specific enzyme fumarate reductase; suppresses egg or larval production and may inhibit subsequent development of eggs or larvae that are passed in the stool.

Indications for Drugs ::

 Indications Treatment of strongyloidiasis (threadworm infection), cutaneous larva migrans (creeping eruption) and visceral larva migrans alone or in conjunction with enterobiasis (pinworm). Secondary therapy for uncinariasis (hookworm: Necator americanus and Ancylostoma duodenale), trichuriasis (whipworm) and ascariasis (large roundworm); alleviation of symptoms of trichinosis during invasive phase.

Drug Dose ::

 Route/Dosage

ADULTS ³ 150 LB (68 kg): PO 1.5 g/dose bid (maximum 3 g/day). ADULTS & CHILDREN 30–150 LB (13.6–68 kg): PO 10 mg/lb/dose (22 mg/kg/dose) (maximum 3 g/day).

Strongyloidiasis, Ascariasis, Uncinariasis, Trichuriasis, Cutaneous Larva Migrans

2 doses daily for 2 successive days (may repeat for some indications).

Trichinosis

2 doses daily for 2–4 successive days.

Visceral Larva Migrans

2 doses daily for 7 successive days.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Unknown. Children: Safety and efficacy in children weighing < 13.6 kg (30 lb) not established. Mixed infections with Ascaris lumbricoides: Thiabendazole may cause these worms to migrate. Drug should not be used prophylactically. Supportive therapy: Anemic, dehydrated or malnourished patients may need concomitant therapy to reverse these conditions.

Drug Side Effects ::

 Adverse Reactions

CV: Hypotension. CNS: Dizziness; fatigue; drowsiness; giddiness; headache; numbness; hyperirritability; eizures; collapse. EENT: Tinnitus; abnormal sensation in eyes; xanthopsia; blurring of vision; rying of mucous membranes; appearance of live ascaris in mouth and nose. GI: Anorexia; nausea; vomiting; diarrhea; epigastric distress. GU: Hematuria; enuresis; malodor of urine; crystalluria. HEMA: Transient leukopenia. HEPA: Jaundice; cholestasis; parenchymal liver damage, transient rise in cephalin flocculation and AST. OTHER: Hypersensitivity reaction (pruritus, fever, facial flush, chills, conjunctival injection (red eye), angioedema, anaphylaxis, skin rashes, erythema multiforme, lymphadenopathy).

Drug Mode of Action ::  

 Action Inhibits helminth-specific enzyme fumarate reductase; suppresses egg or larval production and may inhibit subsequent development of eggs or larvae that are passed in the stool.

Drug Interactions ::

 Interactions

Xanthines: Thiabendazole may increase serum concentrations of theophylline to potentially toxic levels.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Monitor patient closely for signs of hypersensitivity reactions: Stevens-Johnson syndrome and erythema multiforme.
• If anemic, dehydrated or malnourished, provide supportive measures.
• If patient is taking theophylline or aminophylline, monitor theophylline serum levels; dosage adjustment may be necessary.
• Assess patient for possible hypotension after administration.
• Obtain baseline LFTs.

Drug Storage/Management ::

 Administration/Storage

• Shake suspension before administering.
• Administer with food to reduce stomach upset.
• Instruct patient to chew tablets thoroughly before swallowing.
• Store at room temperature.

Drug Notes ::

 Patient/Family Education

• Instruct patient to take medicine with food. No special diets are needed.
• Advise patient that all family members should be treated and that treatment may need to be repeated in 7 days to prevent reinfection.
• Instruct patient to bathe daily and to launder bedlinens, clothes and towels daily. Instruct patient on proper technique for hygiene and hand-washing.
• Advise patient to avoid consuming excessive amounts of caffeine-containing beverages, such as coffee.
• Instruct patient to inform physician immediately of any symptoms of hypersensitivity or overdosage.
• Advise patient that drug can cause drowsiness and dizziness and to use caution while driving or performing other tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.