Article Contents ::
Details About Generic Salt :: Adefovir
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 9B. DRUGS FOR HEPATITIS in 9. HEPATOBILIARY SYSTEM |
| ADEFOVIR |
| NRTI | ANTI-VIRAL |
| PK: D: 0.35-0.39 L/kg M: Intestine E: Urine (45%) |
|
Indications & Dose: HEPATITIS WITH HBeAg NEGATIVE PO Adult 10mg OD 1 yr until HBsAg is cleared Child > 12 yr: Same as adult dose | HEPATITIS WITH HBeAg POSITIVE Chronic PO Adult 10mg OD >1 yr until HBeAg seroconversion and undetectable serum HBV DNA, continue therapy > 6 months after HBeAg seroconversion Child > 12 yr: Same as adult dose |
| Contra: Hypersensitivity
Precautions: Lactic acidosis, renal/hepatic impairment, elderly, children ADR: Serious: hematuria, renal dysfunction, severe hepatomegaly, pneumonia, Others: headache, abdominal pain, nausea, diarrhea, vomiting, rash DDI: Serious Tacrolimus/Ciclosporin enhances nephrotoxicity, Saquinavir/Delavirdine levels are reduced Diet: With/without food Monitor: HIV status, SeCr, LFTs, HBeAg & anti-HBe |