The Brand Name ADEQUET Has Generic Salt :: Quetiapine 

ADEQUET  Is From Company Nicholas Priced :: Rs. 148

ADEQUET have Quetiapine is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Schizophrenia, Bipolar disorder

Drug Dose ::

Adult: PO Schizophrenia Initial: 25 mg twice daily on day 1, increase to 50 mg twice daily on day 2, 100 mg twice daily on day 3 and 150 mg twice daily on day 4. Usual: 300-450 mg/day. Max: 750 mg/day. Bipolar disorder: Manic phase: 50 mg twice daily, increase by 50 mg/dose for each subsequent day till 3rd day. Usual: 400-800 mg/day. Increase slowly if needed. Depressive phase: Initial: 50 mg at bedtime on day 1, 100 mg on day 2, 200 mg on day 3, and 300 mg on day 4. May increase to 400 mg on day 5 and 600 mg on day 8 if needed.

Contraindication ::

Quetiapine is contraindicated in individuals with a known hypersensitivity to this medication or any of its ingredients. Severe CNS depression, bone marrow suppression, coma.

Drug Precautions ::

Cerebrovascular disease or conditions that predispose to hypotension. History of seizures; neuroleptic malignant syndrome; tardive dyskinesia. Monitor glycaemic control, especially in diabetics. Hepatic or renal impairment. Gradual withdrawal is recommended. Monitor for signs of clinical worsening, suicidality or unusual changes in behaviour. Pregnancy and lactation.

Drug Side Effects ::

Headache, asthenia, abdominal pain, back pain, fever, chest pain, postural and orthostatic hypotension, hypertension, constipation, dry mouth, dyspepsia, diarrhoea, leucopenia, elevations in serum transaminase level, weight gain, myalgia, somnolence, dizziness, anxiety, rhinitis, rash, dry skin, ear pain, UTI, syncope, neuroleptic malignant syndrome, variations in WBC count, neutropenia, eosinophilia, elevations in nonfasting serum triglyceride level and total cholesterol, decrease in thyroid hormone levels, prolongation of the QTc interval.

Pregnancy category ::

3

Drug Mode of Action ::  

Quetiapine is an antagonist at multiple neurotransmitter receptors in the brain: Serotonin 5-HT1A and 5-HT2, dopamine D1 and D2, histamine H1 and adrenergic a1 and a2 receptors. It is used in the treatment of schizophrenia and bipolar disorder.

Drug Interactions ::

Increased risk of drowsiness and postural hypotension when used with alcohol. CYP3A4 inducers eg. phenytoin and carbamazepine may decrease plasma levels of quetiapine while CYP3A4 inhibitors eg. ketoconazole and erythromycin may increase its plasma levels.