The Brand Name AVIZINE Has Generic Salt :: Piperazine 

AVIZINE  Is From Company TAJ PH. Priced :: Rs. 4.00/56.40

AVIZINE have Piperazine is comes under Sub class Anthelmintics of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Anthelmintics 

Indications for Drugs ::

Enterobiasis, Ascariasis

Drug Dose ::

Ascariasis Adult: As hydrate: 4.5 g as a single dose repeated once after 14 days. Alternatively, may be given as a preparation with senna in a single dose of 4 g of the phosphate, repeat dose mthly for up to 3 mth if needed; same dosage regimen may also be used to prevent ascariasis. Child: As a single dose, repeated once after 14 days. <1 yr: 120 mg/kg (only upon medical advice), 1-3 yr: 1.5 g, 4-5 yr: 2.25 g, 6-8 yr: 3 g, 9-12 yr: 3.75 g. Alternatively, may be given as a preparation with senna in a single dose of 4 g of the phosphate, repeat dose mthly for up to 3 mth if needed; same dosage regimen may also be used to prevent ascariasis. EnterobiasisAdult: As hydrate: 2.25 g once daily for 7 days, 2nd course may be repeated after an interval of 7 days. Alternatively, may be given as a preparation with senna in a single dose of 4 g of the phosphate, repeat dose after 14 days. Child: <1 yr: 45-75 mg/kg (only upon medical advice), 1-3 yr: 750 mg, 4-6 yr: 1.125 g, 7-12 yr: 1.5 g, >12 yr: same as adult dose. To be taken once daily for 7 days, 2nd course may be repeated after an interval of 7 days. Alternatively, for children >6 yr: May be given as a preparation with senna in a single dose of 4 g of the phosphate; repeat dose after 14 days.

Contraindication ::

Severe renal impairment, epilepsy. Pregnancy.

Drug Precautions ::

Hepatic impairment, neurological conditions, mild to moderate renal impairment. Lactation.

Drug Side Effects ::

Nausea, vomiting, colic, abdominal pain, diarrhoea, urticaria, skin rashes, headache, bronchospasm, dizziness, nystagmus, ataxia, paraesthesia, myoclonic contractions, choreiform movements, muscular incoordination (worm wobble), confusion, EEG abnormalities, blurred vision. Potentially Fatal: Stevens-Johnson syndrome, bronchospasm and angioedema.

Pregnancy category ::

2

Drug Mode of Action ::  

Piperazine is effective against the intestinal nematodes roundworm (Ascaris lumbricoides), pinworm and threadworm (Enterobius vermicularis). It produces a neuromuscular block resulting in muscle paralysis of the worms which are consequently dislodged and expelled in the faeces.

Drug Interactions ::

Antagonism if pyrantel and piperazine are used together. Piperazine may potentiate extrapyramidal effects of chlorpromazine and other phenothiazines.