The Brand Name AVOMINE Has Generic Salt :: Promethazine 

AVOMINE  Is From Company Nicholas Priced :: Rs. 24

AVOMINE have Promethazine is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Allergic conditions, Nausea and vomiting, Motion sickness, Insomnia

Drug Dose ::

Oral Allergic conditions Adult: As hydrochloride: 25 mg at night inreased to 25 mg bid, if needed; alternatively, 10-20 mg bid or tid. Child: As hydrochloride: 5-10 yr: 10-25 mg daily; 2-5 yr: 5-15 mg daily. Doses are given in 1 or 2 divided doses. Renal impairment: Dose reduction may be required. Prophylaxis of motion sickness Adult: As hydrochloride: 20 or 25 mg the night before travelling followed by a similar dose in the morning if needed. Child: As hydrochoride: 5-10 yr: 10 mg; 2-5 yr: 5 mg; doses are given at night before travelling, repeated the following morning if needed. As teoclate: 5-10 yr: 12.5 mg daily starting either on the night before long journeys or 1-2 hr before short journeys. Renal impairment: Dose reduction may be required. Short-term management of insomnia Adult: As hydrochloride: 20-50 mg at night. Child: As hydrochloride: 5-10 yr: 20-25 mg; 2-5 yr; 15-20 mg. Doses are taken at night. May also be given as suppository. Renal impairment: Dose reduction may be required. Parenteral Allergic conditions Adult: As hydrochloride: 25-50 mg, given via IM or slow IV inj or injected into the tubing of a freely running infusion at a concentration of not >25 mg/ml and infused at a rate of not >25 mg/min. Max dose: 100 mg. Child: As hydrochloride: 5-10 yr: 6.25-12.5 mg by deep IM inj. Renal impairment: Dose reduction may be required.

Contraindication ::

Hypersensitivity, coma, porphyria, cardiac disease, hypokalaemia, intra-arterial or SC inj, neonates and young children, pregnancy, lactation.

Drug Precautions ::

Elderly, glaucoma, epilepsy, CVS disease, impaired liver function, asthma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction. May cause drowsiness. For parenteral admin: Drug must be administered carefully and slowly; incorrect admin can lead to severe tissue injury.

Drug Side Effects ::

CNS depression, paradoxical excitation in childn, dryness of mouth, blurring of vision, retention of urine, constipation, glaucoma, tachycardia, headache, hypotension, tinnitus.

Pregnancy category ::

3

Drug Mode of Action ::  

Promethazine, a phenothiazine derivative, blocks postsynaptic dopaminergic receptors in the brain and has a strong ?-adrenergic blocking effect. It competitively binds to H1-receptors.

Drug Interactions ::

Masks ototoxicity of aminoglycoside antibiotics. May enhance the sedative effects of CNS depressants like alcohol, hypnotics, barbiturates and opioids. Potentially Fatal: Ventricular arrhythmias when used with drugs that prolong QT interval.