Article Contents ::
Details About Generic Salt :: Bleomycin
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| BLEOMYCIN |
| CYTOTOXIC GLYCOPEPTIDE ANTIBIOTIC | ANTI-NEOPLASTIC |
| PK: A: Rapid (parenteral, intraperitoneal, intrapleural) D: 22 L/m2 (Vd) M: Hepatic, GI tract, skin, pulmonary, renal & Se E: Urine (50%-70% as active drug) |
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Indications & Dose: HODGKIN’S LYMPHOMA IV/IM/SC Adult 10-20U/m2 once/twice weekly, after 50% response, MD 1U/m2/day (IM/IV) or 5U/m2/wk (IM/IV) | MALIGNANT PLEURAL EFFUSION Intrapleural Adult 50-60U dissolved in 50-100mL of Nacl (0.9%), given through thoracostomy tube | SQUAMOUS CELL CARCINOMA OF HEAD/NECK/SKIN/PENIS/CE IV/IM/SC Adult 10-20U/m2 once/twice weekly | TESTICULAR CARCINOMA IV/IM/SC Adult 10-20U/m2 once/twice weekly |
| Contra: Hypersensitivity
Precautions: Renal impairment, elderly, pulmonary infect, pre-existing impairment of pulmonary function, use of oxygen during surgery ADR: Serious: cardiorespiratory collapse, Pulmonary toxicity, interstitial pneumonitis fibrosis, thrombophlebitis, acute anaphylactoid reactions, TEN, Others: onycholysis, anorexia, weight loss, local reactions, rash, erythema, pruritus, vesiculation, hyperkeratosis, nail changes, alopecia, hyperpigmentation, striae, stomatitis, fever, hyperpyrexia DDI: Serious Vinblastine causes Raynaud’s phenomenon, Cisplatin increases pulmonary toxicity of drug by reduces its renal excretion, Colony-stimulating factors induces pulmonary toxicity of drug, Oxygen leads to serious & potentially fatal pulmonary toxicity, Phenytoin levels reduced Monitor: Pulmonary function tests, renal function, LFTs, chest x-ray, temp, body weight at regular intervals |