The Brand Name CAFIRATE Has Generic Salt :: Caffeine 

CAFIRATE  Is From Company Sun Priced :: Rs. 960

CAFIRATE have Caffeine is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Acute Migraine

Drug Dose ::

Adult: Each tablet contains ergotamine tartrate 2 mg, cyclizine hydrochloride 50 mg and caffeine hydrate 100 mg. Initially, 1 tablet, additional doses of ½-1 tablet may be taken at half-hrly intervals, if needed. To be taken as soon as possible at the 1st warning of a migraine attack. Max: 3 tablets in 24 hr, 4 tablets per attack, 6 tablets per wk and 2 courses of treatment per mth. Ensure an interval of at least 4 days between successive treatment courses.

Contraindication ::

Not to be used with potent inhibitors of CYP3A4 and protease inhibitors. Hyperthyroidism, renal or hepatic impairment. Pre-existing vascular disease including coronary disease, obliterative vascular disease, angina, claudication, peripheral ischaemia, Raynaud’s syndrome and hypertension. Not to be used when there is sepsis. Pregnancy and lactation.

Drug Precautions ::

Not to be taken regularly or used for migraine prophylaxis. Increased risk of arterial constriction and other symptoms of ergotism. Discontinue treatment when symptoms of arterial occlusion occur e.g. numbness and tingling of the extremities. Caution when used in patients with infective hepatitis, cardiac disease or anaemia. GI tract obstructive disease, glaucoma, prostatic hypertrophy or urinary retention may be worsened by cyclizine. May increase risk of retroperitoneal and/or pleuropulmonary fibrosis. Not recommended for use with other vasoconstrictors. Elderly.

Drug Side Effects ::

Increased BP, hypotension, rapid and weak pulse, palpitations, arrhythmias, precordial pain, coronary infarction, fibrotic thickening of the heart valves. Cerebral ischaemia and thrombosis, blurred vision, sleep disturbances, urinary retention, muscle cramps and joint pains. GI symptoms such as nausea, vomiting, constipation, abdominal pain. Dysaesthesia, paraesthesia, formication, tremor, convulsions, headache, extrapyramidal effects. Anxiety, depression, confusion, hallucinations, psychomotor impairment.

Pregnancy category ::

21

Drug Mode of Action ::  

Ergotamine is an alpha-adrenergic blocker with a direct stimulating effect on the smooth muscle of peripheral and cranial blood vessels, it also depresses central vasomotor centers. Caffeine is also a cranial vasoconstrictor.

Drug Interactions ::

0