Article Contents ::
Details About Generic Salt :: Calcitonin
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Drugs affecting Bone Metabolism
| 8I. DRUGS AFFECTING BONE METABOLISM in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| CALCITONIN |
| HORMONE | HYPOCALCEMIC AGENT |
| PK: D: 0.15-0.3 L/kg (Vd) M: Renal, blood & peripheral tissue E: Urine |
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Indications & Dose: BONE LOSS DUE TO SUDDEN IMMOBILITY Acute Prophylactic therapy IM/SC Adult 100U/day in 1–2 divided doses 2–4 wk, reduce to 50U/day at start of mobilisation & continued until fully mobile | HYPERCALCEMIA OF MALIGNANCY Severe Emergency therapy IV Adult Inf up to 10U/kg over at least 6h | IM/SC Adult 100U q6-8h adjust according to response, max 400U q6–8h | PAGET’S DISEASE IM/SC Adult Initially 100U/day MD 50U/day or 50-100U q1-3days | POSTMENOPAUSAL OSTEOPOROSIS IM/SC Adult 100U q48h with dietary calcium & vitamin D supplements | NSL Adult 200U (1 spray) into one nostril daily, with dietary calcium & vitamin D |
| Contra: Hypersensitivity, hypocalcemia
Precautions: History of allergy, renal impairment, HF ADR: Serious: myalgia, HTN, angina, conjunctivitis, bronchospasm, Others: rhinitis, lacrimation abnormality, nasal ulcerations, sinusitis, URTI, flu-like syndrome, lymphadenopathy, back pain, nausea, fatigue, dyspepsia, cystitis, constipation, diarrhea, erythematous rash, depression, abdominal pain DDI: Serious Lithium levels reduced Diet: Monitor: Serum electrolytes & Ca, alkaline phosphatase & 24h urine collection for hydroxyproline excretion, BMD, visualization of nasal mucosa, turbinate, septum & mucosal blood vessels |