Indications & Dose: BONE & JOINT INFECT IV Adult 2g q12h | GYNECOLOGIC/INTRA-ABDOMINAL INFECT/LIFE-THREATENING INFECT IV Adult 2g TID | INFECT IN FEBRILE NEUTROPENIC PATIENTS Empirical therapy IV Adult 2g TID alone or in conjunction with aminoglycoside Child > 2 yr: 50mg/kg TID, max 2g | MENINGITIS IV Adult 2g q8h 3 wk Child Neonates <7 days: 100-150mg/kg/day in 2 or 3 equally divided doses, older neonates & children: 150mg/kg/day in 3 divided doses 3 wk | PNEUMONIA Uncomplicated IV/IM Adult 0.5-1g TID | PSEUDOMONAL LUNG INFECTION IN CYSTIC FIBROSIS IV Adult 30-50mg/kg TID, max 6g/day Child 1 month-18 yr: 50mg/kg TID, max 9g/day | IM Child 1 month-18 yr: 50mg/kg TID, max 9g/day | SKIN/SKIN STRUCTURE INFECT Mild IV/IM Adult 0.5-1g TID | URINARY TRACT INFECT Uncomplicated IV/IM Adult 250mg BID | Complicated IV/IM Adult 500mg BID/TID

Precautions: Sensitivity to ß-lactam antibacterials, renal impairment, false-positive reactions for glucose using copper-reduction reactions, false positive Coombs’ test, history of allergy

ADR: Serious: TEN, transient hepatitis, cholestatic jaundice, reversible interstitial nephritis, blood disorders, arthralgia, anaphylaxis, pseudomembranous colitis, thrombophlebitis, Others: nervousness, sleep disturbances, confusion, hypertonia, dizziness, diarrhea, nausea, vomiting, abdominal discomfort, headache, allergic reactions, erythema multiforme, eosinophilia

DDI: Serious Lincomycin leads to nephrotoxicity, Indomethacin reduces drug clearance

Monitor: Signs & symptoms of anaphylaxis during first dose