Indications & Dose: BACTERIAL EXACERBATIONS OF CHRONIC BRONCHITIS Acute PO Adult 250/500mg BID Child > 13 yr: Same as adult dose | BACTERIAL MAXILLARY SINUSITIS PO Adult 250mg BID 10 days Child >13 yr: Same as adult dose | CELLULITIS IV Adult 1.5g TID Child > 13 yr: Same as adult doseorbital | CHOLECYSTITIS IV Adult 1.5g TID 4-7 days | COMMUNITY-ACQUIRED PNEUMONIA PO Adult 500mg BID | EPIGLOTTITIS PO Child > 3 months-12 yrs: 150mg/kg/day in 3 divided doses 7-10 days | GONORRHEA PO Adult 1g as a single dose (for un-complicated) Child >13 yr: Same as adult dose | IV/IM Adult 750mg TID Child > 13 yr: Same as adult dosedisseminated | Combination therapy IM Adult 1.5g as single dose (administer in 2 different sites with probenecid Child > 13 yr: Same as adult dose | INFECT Complicated/Severe IV/IM Adult 1.5g TID, up to 1.5g QID in life-threatening infect Child > 13 yr: Same as adult dose | LYME DISEASE PO Adult 500mg BID 20 days Child > 13 yr: Same as adult dose | PERIOPERATIVE PROPHYLAXIS IV Adult 1.5g 0.5-1h before procedure, for open heart surgery 1.5g BID to total of 6g Child >13 yr: Same as adult dose | IM Adult 750mg TID Child >13 yr: Same as adult dosefor lengthy procedures | PHARYNGITIS/TONSILLITIS PO Adult 250mg BID 10 days Child >3 months-12 yr: 125mg BID 10 days, >13 yr: Same as adult dose | PNEUMONIA Uncomplicated IV Adult 750mg TID Child >13 yr: Same as adult dose | SECONDARY BACTERIAL INFECT OF ACUTE BRONCHITIS PO Adult 250mg BID 10 days Child >13 yr: Same as adult dose | SKIN/SKIN STRUCTURE INFECT Uncomplicated PO Adult 250/500mg BID 10 days Child > 13 yrs: Same as adult dose | IV/IM Adult 750mg TID Child > 13 yr: Same as adult dose | URINARY TRACT INFECT Uncomplicated PO Adult 125/250mg BID 7-10 days Child > 13 yr: Same as adult dose | Uncomplicated IV/IM Adult 750mg TID Child > 13 yr: Same as adult dose

Precautions: False positive Coombs’ test, penicillin-sensitive patients, history of allergy, renal impairment, false-positive reactions for glucose using copper-reduction reactions, false Jaffé method of measuring creatinine levels

ADR: Serious: Hypersensitivity reactions, bleeding complications, platelet dysfunction, blood disorders, anaphylaxis, hypoprothrombinemia, nephrotoxicity, acute interstitial nephritis, hepatitis, cholestatic jaundice, transient increases in liver enzyme values, convulsions, CNS toxicity, overgrowth of non-susceptible organisms, pseudomembranous colitis, thrombophlebitis, SJS, TEN, Others: mild-to-moderate hearing loss, skin rashes, urticaria, eosinophilia, fever, nausea, vomiting, diarrhea, local reactions, pain at inj site

DDI: Serious Coumarins increased risk of hemorrhage, Tobramycin/Gentamicin increases risk of nephrotoxicity, Ranitidine/Famotidine reduces drug bioavailability

Diet: With food

Monitor: Signs & symptoms of anaphylaxis during first dose, with prolonged therapy, renal function test, LFTs, hematologic function periodically & PT