The Brand Name CHEMEDOX-HT Has Generic Salt :: Doxycycline 

CHEMEDOX-HT  Is From Company Chemo D. Priced :: Rs. 19.2

CHEMEDOX-HT have Doxycycline is comes under Sub class Tetracyclines of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Tetracyclines 

Indications for Drugs ::

Acne, Susceptible infections, Syphilis, Uncomplicated gonorrhoea, Relapsing fever and louse-borne typhus, Scrub typhus

Drug Dose ::

Adults: Two capsules at a time or one capsule every 12 hours for the first day followed by one capsule per day. Children: Over 8 years or weighing 45 Kg or less: 4.4 mg/Kg on the first day followed by 2.2 mg/Kg daily. Acute gonococcal urethritis: 1 capsule twice daily for 2 to 4 days in male and until a cure has been obtained in female. Chlamydial infections: 1 capsule twice daily for 7 days. Syphilis: 3 capsules in divided doses for 10 days.

Contraindication ::

It is contraindicated to patients with known hypersensitivity to any of the tetracyclines. It is also contraindicated in severe hepatic disorder and patients with systemic lupas erythematosus. Concomitant intake of alkalis, antacids and iron may interfere with the absorption of Doxycycline. It is advisable to avoid giving doxycycline in conjunction with penicillin. Doxycycline should not be used in pregnant women unless, in the judgment of the physician, it is essential for the welfare of the patient.

Drug Precautions ::

The use of drugs of tetracycline group during tooth development (last half of pregnancy, infancy and childhood to the age of 12 years) may cause permanent discoloration of the teeth. Tetracyclines, therefore, should not be used in this age group unless other drugs are not likely to be effective or are contraindicated.

Drug Side Effects ::

Epigastric distress, abdominal discomfort, nausea, and vomiting may occur. Long term therapy with Doxacil® may produce changes in the peripheral blood. Various skin reactions including rashes, urticaria, exfoliative dermatitis.

Pregnancy category ::

4

Drug Mode of Action ::  

Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. It has bacteriostatic activity against a broad range of gm+ve and gm-ve bacteria.

Drug Interactions ::

Concomitant use w/ isotretinoin is known to cause pseudotumour cerebri. Prolonged prothrombin time w/ anticoagulants (e.g. warfarin). May interfere w/ the bactericidal action of penicillin. Impaired absorption w/ antacids containing Al, Ca, or Mg, oral Zn, Fe salts, and bismuth preparations. Increased metabolism w/ phenobarbital, carbamazepine, primidone and phenytoin. Risk of breakthrough bleeding w/ oral contraceptives. Increased plasma concentration of ciclosporin. Decreased half-life w/ hepatic enzymes inducers (e.g. rifampicin). Potentially Fatal: Concurrent use w/ methoxyflurane may result to fatal renal toxicity.