The Brand Name COMEDOLYTIC Has Generic Salt :: Tretinoin 

COMEDOLYTIC  Is From Company Fem care Priced :: Rs. 60

COMEDOLYTIC have Tretinoin is comes under Sub class Drugs for Acne of  Main Class Skin

Main Medicine Class:: Skin  Sub Medicine Class :: Drugs for Acne 

Indications for Drugs ::

Acne, Mottled hyperpigmentation, Roughness and fine wrinkling of photodamaged skin

Drug Dose ::

Adult: Topical Acne As 0.01-0.1% cream/gel/alcoholic soln: Apply 1-2 times/day. Mottled hyperpigmentation, roughness and fine wrinkling of photodamaged skin As 0.02-0.05% preparation: Apply once daily at night.

Contraindication ::

Hypersensitivity to retinoids. Application to eczematous, sunburnt or abraded skin. Pregnancy, lactation.

Drug Precautions ::

Topical: avoid concomitant topical applications, esp keratolytic agents. Avoid exposure to sunlight, UV light and weather extremes (e.g. cold). Keep away from eyes, mouth, angles of nose, mucous membranes or open wounds. In case of severe local erythema, oedema, blistering or crusting, use less frequently or discontinue. Avoid medicated or drying soaps, abrasive soaps and cleansers, frequent washing and harsh scrubbing. Avoid use of topical preparations with high concentrations of alcohol, menthol, spices or lime.

Drug Side Effects ::

Initial exacerbation of symptoms, skin irritation, stinging on application, oedema, blistering, crusting of the skin, erythema, scaling, photosensitivity, temporary hypo/hyperpigmentation.

Pregnancy category ::

3

Drug Mode of Action ::  

Tretinoin is a trans-retinoic acid form of vitimin A. It stimulates mitosis and turnover of follicular epithelial cells and reduce their cohesiveness. This facilitates extrusion of existing comedones and prevents formation of new comedone. It also exhibits thinning effect on the stratum corneum. In acute promyelocytic leukaemia, it induces cellular differentiation and decreases proliferations.

Drug Interactions ::

Enhances percutaneous absorption of minoxidil. Increased risk of fatal thrombotic complications with antifibrinolytic. Increased tretinoin concentrations with azole antifungals. Enhances peeling action of sulphur, resorcinol, benzoyl peroxide, salicylic acid. Increased photosensitivity with photosensitising medications eg, thiazides, tetracyclines, fluoroquinolones, phenothiazines and sulfonamides. Potentially Fatal: Increased risk of intracranial pressure with tetracyclines.