The Brand Name COZIT Has Generic Salt :: Tinidazole 

COZIT  Is From Company Emcure Priced :: Rs. 55

COZIT have Tinidazole is comes under Sub class Anti Amoebics of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Anti Amoebics 

Indications for Drugs ::

Giardiasis, H. pylori infection, Surgical Prophylaxis, Bacterial vaginosis, Intestinal amoebiasis, Trichomoniasis, Acute necrotising ulcerative gingivitis, Hepatic amoebiasis

Drug Dose ::

Adult: PO Bacterial vaginosis; Acute necrotising ulcerative gingivitis; Giardiasis; Trichomoniasis 2 g as single dose. Child: >3 yr 50-75 mg/kg as single dose, repeat if necessary. Max: 2 g/day. Bacterial vaginosis: May repeat the next day. Susceptible infections 2 g on 1st day, then 1 g once daily for 4-5 days. Surgical prophylaxis 2 g 12 hr pre-op. Eradication of H. pylori associated w/ peptic ulcer disease W/ clarithromycin and omeprazole: 500 mg twice daily for 7 days. Intestinal amoebiasis 2 g once daily for 2-3 days. Hepatic amoebiasis 1.5-2 g once daily for 3-6 days. Child: >3 yr 50-60 mg/kg daily for 3 consecutive days. Max: 2 g/day. IV Susceptible infections Initial: Infuse 800 mg, followed by 800 mg/day or 400 mg twice daily till PO can be given. Surgical prophylaxis 1.6 g as single infusion pre-op.

Contraindication ::

Blood dyscrasias, organic neurologic disorders, hypersensitivity to 5-nitroimidazole derivatives, porphyria. Lactation, pregnancy (1st trimester).

Drug Precautions ::

Alcohol should be avoided until 72 hr after stopping therapy. Discontinue if abnormal neurological signs (e.g. dizziness, incoordination, ataxia) develop. CNS diseases, pregnancy (2nd and 3rd trimester).

Drug Side Effects ::

Metallic taste, nausea, headache, vomiting, dark urine, flushing, anorexia, diarrhoea, tiredness, transient leucopenia. Potentially Fatal: Hypersensitivity.

Pregnancy category ::

3

Drug Mode of Action ::  

Tinidazole, a 5-nitroimidazole derivative w/ antimicrobial actions similar to metronidazole, is active against both protozoa (e.g. Trichomonas vaginalis, Entamoeba histolytica and Giardia lamblia) and obligate anaerobic bacteria. It damages DNA strands or inhibits DNA synthesis in microorganism.

Drug Interactions ::

May potentiate the effects of oral anticoagulants resulting to prolonged prothrombin time.