Article Contents ::
Details About Generic Salt :: Darifenacin
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 10D. DRUGS ACTING ON BLADDER in 10. GENITO-URINARY SYSTEM |
| DARIFENACIN |
| ANTI-CHOLINERGIC | GENITOURINARY ANTI-SPASMODIC |
| PK: D: ~163 L (Vdss) M: Hepatic E: Urine (60%), feces (40%) as inactive metabolites |
|
Indications & Dose: MANAGEMENT OF OVERACTIVE BLADDER PO Adult Initially 7.5mg/day, may increase to 15mg/day as early as 2 wk after therapy begins |
| Contra: Hypersensitivity, uncontrolled narrow-angle glaucoma, urinary retention, paralytic ileus, GI/GU obstruction, gastric retention
Precautions: Decreased GI motility, constipation, hiatal hernia, reflux esophagitis, ulcerative colitis, controlled narrow-angle glaucoma, hepatic impairment, myasthenia gravis, prostatic hyperplasia (nonobstructive)/clinically-significant bladder outlet obstruction, concurrent treatment with strong CYP3A4 inhibitors, children ADR: Serious: HTN, peripheral edema, UTI, urinary retention, abnormal vision, flu-like syndrome, hypersensitivity reactions, Others: palpitation, angioedema, confusion, hallucinations, bronchitis/pharyngitis/rhinitis/sinusitis, Xerostomia, constipation, weakness, arthralgia, back pain, dry eyes, headache, dizziness, dry skin, pruritus, rash, dyspepsia, abdominal pain, nausea, vomiting, weight gain DDI: Serious Digoxin exposure increases by drug, Ketoconazole markedly increases drug exposure, Rifampicin markedly reduces the exposure to drug, Fluconazole/Erythromycin modestly increases drug exposure Diet: With/without food |