The Brand Name DORSENZ EYE Has Generic Salt :: DORZOLAMIDE 

DORSENZ EYE  Is From Company SENSES Priced :: Rs. 180

DORSENZ EYE have DORZOLAMIDE is comes under Sub class Anti Glaucoma Drugs of  Main Class Ocular

Main Medicine Class:: Ocular  Sub Medicine Class :: Anti Glaucoma Drugs 

Indications for Drugs ::

Open-angle glaucoma, Ocular hypertension

Drug Dose ::

Adult: As soln containing timolol 0.5% and dorzolamide 2%: Instill 1 drop twice daily. Renal impairment: CrCl (ml/min) <30 Not recommended. Contraindication ::

Hypersensitivity to any of the components or sulphonamide. History or current bronchial asthma, severe COPD, sinus bradycardia, 2nd or 3rd degree AV block, overt cardiac failure, cardiogenic shock, CrClr <30 ml/min and hyperchloraemic acidosis. Drug Precautions ::

Hepatic impairment, mild to moderate renal impairment, children <2 yr. Avoid use in pregnancy and lactation. Prinzmetal's angina, cardiac disease, hypotension, myasthenia gravis, history of renal calculi, history of intra-ocular surgery, pre-existing chronic corneal defects. May worsen severe peripheral and central circulatory disorders. May mask symptoms of hypoglycaemia and hyperthyroidism. Withdraw gradually, especially in patients with coronary heart disease. Discontinue treatment at the first signs or symptoms of cardiac failure. Contact lenses to be removed before eyedrop application and wait at least 15 minutes before reinsertion. Apply other eyedrops 10 minutes apart. May affect ability to drive or operate machinery as it may cause blurred vision. Drug Side Effects ::

Ocular irritation, burning, stinging, itching and tearing; conjunctival inj, eyelid inflammation or irritation, corneal erosion, blurred vision, headache, sinusitis, taste perversion, nausea, fatigue. Potentially Fatal: Cardiac failure, bronchospasm.

Pregnancy category ::

3

Drug Mode of Action ::  

Timolol maleate, a nonselective ?-adrenergic blocker, reduces aqueous humor formation. Dorzolamide, a carbonic anhydrase inhibitor, has actions similar to acetazolamide. By inhibiting carbonic anhydrase in the ciliary processes of the eye, dorzolamide decreases aqueous humor secretion. Used together, there is additional intraocular pressure reduction compared to using either component alone, but the reduction is not as much as concomitant admin of dorzolamide tid and timolol bid.

Drug Interactions ::

Additive hypotension and bradycardia with oral calcium channel blockers, catecholamine-depleting drugs or ?-blockers, antiarrhythmics (e.g. amiodarone), digitalis glycosides, parasympathomimetics, narcotics and MAOIs. Additive systemic side effects with oral carbonic anhydrase or ?-blockers; avoid concurrent use. Additive systemic ?-blockade with CYP2D6 inhibitors (e.g. quinidine, SSRIs) and timolol.