The Brand Name DOXOTERO Has Generic Salt :: Doxorubicin 

DOXOTERO  Is From Company HETERO HC. Priced :: Rs. 165

DOXOTERO have Doxorubicin is comes under Sub class Anti Neoplastic Agents of  Main Class Anti Neoplastic Agents

Main Medicine Class:: Anti Neoplastic Agents  Sub Medicine Class :: Anti Neoplastic Agents 

Indications for Drugs ::

AIDS-related Kaposi’s sarcoma, Ovarian carcinoma, Metastatic breast carcinoma, bladder carcinoma

Drug Dose ::

Adult: IV AIDS-related Kaposi’s sarcoma As pegylated liposome: 20 mg/m2 once 2-3 wkly. Ovarian carcinoma As pegylated liposome: 50 mg/m2 once 4 wkly. Metastatic breast carcinoma w/ cyclophosphamide: 60-75 mg/m2 once 3 wkly. Irrigation Local malignant neoplasms in the bladder As 1 mg/mL soln: Instill 50 mL into the bladder for 1 hr once mthly.

Contraindication ::

Cardiac disease, neonates, pregnancy and lactation, prior irradiation to mediastinum. IM/SC admin. Severe myelosuppression due to previous treatment with antitumour agents or radiotherapy.

Drug Precautions ::

Elderly, children, hepatic impairment. Monitor blood counts and ECG.

Drug Side Effects ::

Leucopenia, thrombocytopenia, nausea, vomiting, diarrhoea. Rarely facial flushing, rash, alopecia. Blurred vision, headache, seizures, paraesthesia, confusion, malaise, lethargy, skin pigmentation. Potentially Fatal: Bone marrow suppression, cardiotoxicity.

Pregnancy category ::

4

Drug Mode of Action ::  

Doxorubicin is a cytotoxic anthracycline antibiotic. The cytotoxic action results from its binding to DNA and inhibition of nucleic acid synthesis. Doxorubicin has been shown to produce regression in a variety of disseminated malignancies.

Drug Interactions ::

Doxorubicin interacts with a number of other drugs e.g. antibiotics (aminoglycosides), steroids, aminophylline and propranolol. Potentially Fatal: Cholestasis induced by mercaptopurine may be potentiated by concurrent administration of the drug. Toxicity may be increased if streptozocin is given concurrently.