The Brand Name ENBENOL Has Generic Salt :: Albendazole 

ENBENOL  Is From Company Ind-Swift Priced :: Rs. 306.25

ENBENOL have Albendazole is comes under Sub class Anthelmintics of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Anthelmintics 

Indications for Drugs ::

Helminthiasis, Echinococcosis, Neurocysticercosis, Enterobiasis, Ascariasis, Hookworm infections, Strongyloidiasis, Giardiasis, Filariasis

Drug Dose ::

Adult: PO Echinococcosis >60 kg: 400 mg twice daily; <60 kg: 15 mg/kg/day (max: 800 mg/day) in 2 divided doses. Duration: 28 days/cycle. Cystic echinococcosis: Up to 3 cycles w/ 14 treatment-free days in between cycles. Alveolar echinococcosis: Treatment cycles may need to be continued for mths or yrs w/ 14 treatment -free days in between cycles. Neurocysticerosis >60 kg: 400 mg twice daily; <60 kg: 15 mg/kg/day (max: 800 mg/day) in 2 divided doses. Duration: 8-30 days. Intestinal nematode infections 400 mg as a single dose. Strongyloidiasis 400 mg 1-2 times/day for 3 consecutive days, may repeat after 3 wk if needed. Giardiasis 400 mg/day for 5 days. Ascariasis; Enterobiasis; Hookworm infections 400 mg as a single dose. Child: >2 yr: 400 mg as a single dose; 1-2 yr: 200 mg as a single dose.

Contraindication ::

Pregnancy and lactation. Neonates. Hypersensitivity, liver impairment.

Drug Precautions ::

Monitor blood counts and liver function. Administer within 7 days of start of normal menstruation in women of childbearing age. Adequate nonhormonal contraceptive measures must be taken during and for 1 mth after therapy. Perform liver function tests and blood counts before and every 2 wk during high dose therapy of hydatid disease.

Drug Side Effects ::

GI discomfort, headache, nausea, dizziness, allergic reactions, pruritus, raised liver enzymes, alopecia and dry mouth. Potentially Fatal: Bone marrow depression.

Pregnancy category ::

3

Drug Mode of Action ::  

Albendazole sulfoxide (active metabolite), causes selective degeneration of cytoplasmic microtubules in intestinal and tegmental cells of intestinal helminths and larvae; glycogen is depleted, glucose uptake and cholinesterase secretion are impaired and desecratory substances accumulate intracellulary. ATP production decreases, causing energy depletion, immobilisation and worm death.

Drug Interactions ::

Increased serum concentrations w/ dexamethasone, praziquantel and cimetidine. Decreased serum concentrations w/ aminoquinoline (antimalarials), carbamazepine, phenobarbital, and phenytoin.