Article Contents ::
Details About Generic Salt :: Febuxostat
Main Medicine Class:: Musculoskeletal Disorders , Pain Sub Medicine Class :: Anti Gout Drugs
| 12B. ANTI-GOUT DRUGS in 12. MUSCULOSKELETAL DISORDERS & PAIN |
| FEBUXOSTAT |
| XANTHINE OXIDASE INHIBITOR | ANTI-GOUT |
| PK: A: >49% D: Vss: 50L M: Hepatic E: Urine & feces |
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Indications & Dose: GOUT PO Adult Initially 40mg OD with NSAID or colchicine for 6 month to prevent gout flare upon initiation of therapy, may increase to 80mg OD in patient who do not achieve serum uric acid level <6mg/dL after 2 wk |
| Contra: Concurrent use with azathioprine/mercaptopurine/theophylline
Precautions: Severe hepatic impairment ADR: Serious: LFT abnormalities, arthralgia, ECG abnormalities, angioedema, Others: renal insufficiency, Rash, altered urine output, vomiting, weight gain/loss, abdominal discomfort, alopecia, anemia Monitor: Signs & symptoms of MI, stroke, LFT, serum uric acid level |