The Brand Name GENTIN Has Generic Salt :: Gabapentin 

GENTIN  Is From Company PSYCOREM Priced :: Rs. 300.00/800.00

GENTIN have Gabapentin is comes under Sub class Anti Epileptics of  Main Class Nervous System

Main Medicine Class:: Nervous System  Sub Medicine Class :: Anti Epileptics 

Indications for Drugs ::

Epilepsy, Neuropathic pain, Partial Seizures, Hot flashes, Fibromyalgia, Postherpetic Neuralgia, Pain from diabetic neuropathy.

Drug Dose ::

Adult: PO: Neuropathic pain: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg daily to maximum 1800 mg daily in three divided doses. Partial seizure/epilepsy: 300 mg on day-1, then 300 mg twice on day-2, then 300 mg thrice on day-3, then increase the dose according to response in steps of 300 mg daily to maximum 2400 mg daily in three divided doses. In case of children: For 6-12 years – 10 mg/kg on day-1, then 20 mg/kg on day-2, then 25-35 mg/kg daily in 3 divided doses. Maintenance dose is 900 mg daily (body weight 26-36 Kg) or 1.2 gm daily (body weight 37-50 Kg). Renal impairment: Haemodialysis: Loading dose: 300-400 mg followed by 200-300 mg after each 4 hr of haemodialysis. CrCl (ml/min) <15 300 mg on alternate days to 300 mg daily. 15-29 300 mg on alternate days to 600 mg daily. 30-49 300-900 mg daily. 50-79 600-1,800 mg daily. Contraindication ::

Hypersensitivity. Lactation.

Drug Precautions ::

Discontinuation or transfer from other antiepileptics, history of psychotic illness; renal impairment; pregnancy. Gradual withdrawal over at least 7 days to prevent an increase in seizure frequency.

Drug Side Effects ::

Somnolence, dizziness, ataxia, weakness, paraesthesia, fatigue, headache; nystagmus, diplopia; nausea, vomiting, wt gain, dyspepsia; rhinitis; tremor; leucopenia; altered LFTs; Stevens-Johnson syndrome.

Pregnancy category ::

3

Drug Mode of Action ::  

Gabapentin is structurally related to the neurotransmitter GABA but is neither a GABA agonist nor antagonist. High affinity gabapentin binding sites are located throughout the brain. These sites correspond to the presence of voltage-gated Ca channels particularly controlling the ?-2/?-1 subunit. This channel appears to be located presynaptically and may modulate the release of excitatory neurotransmitters which participate in epileptogenesis and nociception.

Drug Interactions ::

May increase plasma level w/ morphine. Reduced absorption w/ antacids.