The Brand Name HEKSI Has Generic Salt :: Trihexyphenidyl 

HEKSI  Is From Company KIVI HC. Priced :: Rs. 14.3

HEKSI have Trihexyphenidyl is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Extrapyramidal symptoms, Parkinsonism (postencephalitic, arteriosclerotic & idiopathic)

Drug Dose ::

Prophylaxis of drug-induced extrapyramidal symptoms: Adult: Initially, 1 mg daily, increased gradually to usual maintenance dose of 5-15 mg daily in 3-4 divided doses. Max dose: 15 mg daily. Elderly: May require smaller doses. Idiopathic Parkinsonism: Adult: Initially, 1 mg daily, increased gradually over a period of several days in steps of 2 mg, up to 6-10 mg daily in 3-4 divided doses according to response. For advanced cases: 12-15 mg daily in 3-4 divided doses. For postencephalitic patients: Larger doses may be required. Elderly: May require smaller doses. Max Dosage: 15 mg daily. Concomitant Use with Levodopa: When trihexyphenidyl HCl is used concomitantly with levodopa, the usual dose is 3-6 mg daily.

Contraindication ::

Patients with closed-angle glaucoma, chronic pulmonary disease, sick sinus syndrome, thyrotoxicosis, cardiac failure with tachycardia.

Drug Precautions ::

Glaucoma, obstructive disease of GI or genitourinary tracts. In elderly males with possible prostatic hypertrophy. Liver and renal disorders. Pregnancy and lactation.

Drug Side Effects ::

Dry mouth, blurring of vision, constipation, urinary retention, glaucoma, confusion, drowsiness, restlessness, hallucinations.Potentially Fatal: Arrhythmias, AV dissociation, multiple ventricular ectopics.

Pregnancy category ::

3

Drug Mode of Action ::  

Trihexyphenidyl HCl is a tertiary amine antimuscarinic which exerts a direct inhibitory effect on the parasympathetic nervous system. It also exhibits a direct spasmolytic action on smooth muscle, weak mydriatic, antisialagogue and cardiovagal blocking effects.

Drug Interactions ::

Increased antimuscarinic side effects w/ phenothiazines, clozapine, antihistamines, disopyramide, nefopam and amantadine. Synergistic effect when concomitantly used w/ TCAs. Concurrent admin w/ MAOIs may cause dry mouth, blurred vision, urinary hesitancy or retention and constipation. May antagonise effect of metoclopramide and domperidone on GI function. Reduced absorption of levodopa. May antagonise effect of parasympathomimetics.