The Brand Name LACTONE Has Generic Salt :: Spironolactone 

LACTONE  Is From Company Sun Priced :: Rs. 11

LACTONE have Spironolactone is comes under Sub class Diuretics of  Main Class Genito Urinary System

Main Medicine Class:: Genito Urinary System  Sub Medicine Class :: Diuretics 

Indications for Drugs ::

Oedema, Hirsutism, Hypertension, Hepatic cirrhosis w/ ascites and oedema, Hyperaldosteronism, Severe CHF, Hypokalaemia

Drug Dose ::

Adult: PO Oedema Initial: 100 mg/day, up to 400 mg/day based on response. Child: Neonates: 1-2 mg/kg daily; 1 mth-12 yr: 1-3 mg/kg daily; 12-18 yr: 50-100 mg daily. To be given in 1-2 divided doses. Elderly: Initially, 25-50 mg/day in 1-2 divided doses, may increase by 25-50 mg every 5 days when necessary. Hepatic cirrhosis w/ ascites and oedema Depending on urinary Na/K ratio: If >1: Initial: 100 mg/day and if <1: Initial: 200-400 mg/day. Diagnosis of primary hyperaldosteronism 400 mg/day for 3-4 wk. Pre-op management of hyperaldosteronism 100-400 mg/day. HTN As monotherapy: 25-50 mg/day, up to 100 mg/day if needed. Severe CHF W/ ACE inhibitor and loop diuretic: Initial: 12.5-25 mg/day, up to 50 mg/day after 8 wk. Diuretic-induced hypokalaemia 25-100 mg/day. Hirsutism 50-200 mg/day. Renal impairment: CrCl (ml/min) 10-50 Recommended dosing interval: Every 12-24 hr. <10 Avoid use. Contraindication ::

Anuria, hyperkalaemia, acute or progressive renal insufficiency. Addison’s disease.

Drug Precautions ::

Patients at risk of developing hyperkalaemia and acidosis; monitor serum electrolytes; renal and hepatic impairment; DM; elderly; pregnancy.

Drug Side Effects ::

Fluid or electrolyte imbalance, gynaecomastia, GI upset, drowsiness, headache, hyponatraemia; tachycardia, hypotension, oliguria, hyperkalaemia; confusion, weakness, paraesthesia, hirsutism, mental disturbances, menstrual irregularities, loss of libido and impotence. Potentially Fatal: Fatal hyperkalaemia in combination with ACE inhibitors and previous renal impairment; agranulocytosis.

Pregnancy category ::

3

Drug Mode of Action ::  

Spironolactone acts on the distal renal tubules as a competitive antagonist of aldosterone. It increases the excretion of sodium chloride and water while conserving potassium and hydrogen ions.

Drug Interactions ::

Sodium excretion effect may be inhibited by aspirin. May reduce ulcer-healing properties of carbenoxolone. Increased risk of nephrotoxicity when used with NSAIDs or ciclosporin. Hyperkalaemia may occur if given with potassium supplements, ACE inhibitors, angiotensin II antagonists, NSAIDs, ciclosporin or trilostane. May increase risk of orthostatic hypotension when used with barbiturates, narcotics or alcohol. May reduce vascular responsiveness to pressor amines. May increase half-life of digoxin. Potentially Fatal: Increased risk of lithium toxicity when used concurrently.