Article Contents ::
Details About Generic Salt :: Leflunomide
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 12D. ANTI-RHEUMATIC DRUGS (DMARDS) in 12. MUSCULOSKELETAL DISORDERS & PAIN |
| LEFLUNOMIDE |
| IMMUNE MODULATOR | ANTI-RHEUMATIC |
| PK: D: 0.13 L/kg (Vd) M: Hepatic E: Feces (48%), urine (43%) |
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Indications & Dose: PSORIATIC ARTHRITIS PO Adult Loading dose: 100mg OD 3 days, MD 20mg OD | RHEUMATOID ARTHRITIS PO Adult Loading dose: 100mg OD 3 days, MD 10-20mg OD |
| Contra: Hypersensitivity, immunocompromised patients, severe infect, hepatic impairment, moderate-to-severe renal impairment, severe hypoproteinemia, bone-marrow dysplasia, live vaccines, suspected pregnancy
Precautions: History of TB, history of significant hematologic abnormalities ADR: Serious: Chest pain, HTN, pneumonia, abnormal LFTs, Others: Headache, dizziness, asthenia, alopecia, rash, dry skin, weight loss, rhinitis, pharyngitis, nausea, vomiting, diarrhea, abdominal pain, dyspepsia, gastroenteritis, mouth ulcers, UTI, hypokalemia, joint pain/disorders, bronchitis DDI: Serious Methotrexate increases adverse effects of drug (hepatotoxicity & hematotoxicity), Warfarin increases INRs with bleeding complications, Itraconazole may cause hepatic failure, Colestyramine/Charcoal/Rifampicin reduces active metabolite of drug Diet: With/without food Monitor: CBC, serum phosphate, liver transaminases |
