Article Contents ::
Details About Generic Salt :: Lenalidomide
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| LENALIDOMIDE |
| ANGIOGENESIS INHIBITOR, IMMUNOMODULATOR | ANTI-NEOPLASTIC |
| PK: A: Rapid E: Urine |
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Indications & Dose: MULTIPLE MYELOMA Combination therapy PO Adult 25mg/day given for 21 days of a 28 day treatment cycle. Give along with dexamethasone [40mg/day on 1-4, 9-12 & 17-20 days of first 4 cycles & repeat only 1-4 days of each cycle thereafter] | MYELODYSPLASTIC SYNDROME WITH 5Q DELETION PO Adult 10mg/day |
| Contra: Hypersensitivity, epoetins/drugs that increases risk of thrombosis (HRT, hormonal contraceptives)
Precautions: renal impairment ADR: Serious: hypotension, tremor, hypoaesthesia, peripheral neuropathy, cardiac disorders, hepatotoxicity, hypothyroidism, hypomagnesemia, hypocalcemia, sinusitis, rhinitis, bronchitis, hypoxia, Anemia, neutropenia, thrombocytopeni, DVT, PE, muscle cramp, Others: GI disturbances, pruritus, rash, fatigue, fatigue, insomnia DDI: Others Digoxin levels slightly increase Monitor: CBC, SeCr, LFT, thyroid function test, ECG, for thromboembolism |