Article Contents ::
Details About Generic Salt :: Letrozole
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| LETROZOLE |
| AROMATASE INHIBITOR | ANTI-NEOPLASTIC |
| PK: A: Rapid & well absorbed D: ~1.9 L/kg (Vd) M: Hepatic E: Urine |
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Indications & Dose: ADVANCED BREAST CANCER IN POSTMENOPAUSAL WOMEN PO Adult 2.5mg OD continue until tumor progression for first or second line treatment | EARLY BREAST CANCER IN POSTMENOPAUSAL WOMEN PO Adult 2.5mg OD 5yr (optimal duration unknown) or continue until tumor progression as extended adjuvant therapy given after 5yr of tamoxifen, discontinue at relapse | Adjuvant therapy PO Adult 2.5mg OD 5yr (optimal duration unknown), discontinue at relapse |
| Contra: Anticipated pregnancy, hypersensitivity
Precautions: Hepatic impairment, osteoporosis ADR: Serious: Edema, hypercholesterolemia, arthritis, BMD decreased/osteoporosis, dyspnea, chest pain, HTN, CVA, hypercalcemia, UTI, vaginal hemorrhage, cataract, secondary malignancy, Others: infect, myalgia, diarrhea, vomiting, weight loss, insomnia, depression, rash, diaphoresis, hot flashes, nausea, weight gain, constipation, weakness, headache, dizziness, fatigue Diet: With/without food Monitor: CBC, TFT, serum electrolytes, TC, transaminases & creatinine, BP, bone density |