The Brand Name METROGYL Has Generic Salt :: ORNIDAZOLE 

METROGYL  Is From Company Lekar Priced :: Rs. 39

METROGYL have ORNIDAZOLE is comes under Sub class Anti Amoebics of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Anti Amoebics 

Indications for Drugs ::

Surgical Prophylaxis, Amoebiasis, Hereditary angioedema, Trichomoniasis, Anaerobic bacterial infections, Amoebic dysentery

Drug Dose ::

Adult: PO Amoebiasis 0.5 g twice daily for 5-10 days. Amoebic dysentery 1.5 g once daily for 3 days. Giardiasis 1-1.5 g once daily for 1-2 days. Trichomoniasis 1.5 g once daily for 5 days. Treat sexual partners concomitantly.

Contraindication ::

Hypersensitivity to ornidazole or to other nitroimidazole derivatives.

Drug Precautions ::

Renal and hepatic impairment. CNS diseases e.g. epilepsy or multiple sclerosis. May impair ability to drive or operate machinery. Pregnancy and lactation.

Drug Side Effects ::

Somnolence, headache, nausea, vomiting, dizziness, tremor, rigidity, poor coordination, seizures, tiredness, vertigo, temporary loss of consciousness and signs of sensory or mixed peripheral neuropathy, taste disturbances, abnormal LFTs, skin reactions.

Pregnancy category ::

0

Drug Mode of Action ::  

Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.

Drug Interactions ::

May decrease absorption of oral fat-soluble vitamins, amiodarone, propafenone. May decrease plasma levels of ciclosporin. May alter the effects of warfarin (monitor INR). May elevate plasma levels of pravastatin.