Article Contents ::
Details About Generic Salt :: Montelukast
Main Medicine Class:: Respiratory System Sub Medicine Class :: Drugs For Asthma,COPD,ARDS
| 14C. ANTI-ALLERGICS in 14. IMMUNOLOGY & ALLERGY |
| MONTELUKAST |
| LEUKOTRIENE RECEPTOR ANTAGONIST | ANTI-ASTHMA, ANTI-ALLERGIC |
| also comes under 6A. Drugs For Asthma/COPD/ARDS in 6. Respiratory System, |
| PK: A: Rapid D: 8-11 L (Vd) M: Hepatic E: feces via bile |
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Indications & Dose: ASTHMA PO Adult 10mg OD Child 12-23 month: 4mg OD, 2-5 yr: 4mg OD, 6-14 yr: 5mg OD | EXERCISE-INDUCED ASTHMA Prophylactic therapy PO Adult 10mg/day 2h before exercise, additional doses should not be given within 24h Child >15yr: Same as adult dose | PERENNIAL/SEASONAL ALLERGIC RHINITIS PO Adult 10mg OD Child 6-23 month: 4mg OD, 2-5yr: 4mg OD, 6-14 yr: 5mg OD, >15yr: 10mg OD | SEASONAL ALLERGIC RHINITIS PO Adult 10mg OD Child 2-5yr: 4mg OD, 6-14 yr: 5mg OD, >15yr: 10mg OD |
| Contra: Hypersensitivity, hepatic impairment/cirrhosis, avoid monotherapy for prevention of exercise-induced bronchospasm, avoid drug in asthma patients sensitivity to aspirin or NSAIDs
Precautions: Acute asthma ADR: Serious: Hypersensitivity reactions, increased ALT/AST concentrations, Churg-Strauss syndrome, arthralgia, myalgia, Others: Dizziness, fatigue, headache, fever, dyspepsia, gastroenteritis, weakness, cough, nasal congestion, sinusitis, epistaxis, URTI DDI: Serious Prednisone leads to severe edema, Phenytoin/Phenobarbital/Rifampicin reduces drug levels Monitor: Mood or behavior changes, including suicidal thinking & behavior |
