The Brand Name NALYXAN Has Generic Salt :: Naproxen 

NALYXAN  Is From Company HETERO HC. Priced :: Rs. 25.4

NALYXAN have Naproxen is comes under Sub class Analgesics , Anti inflammatory Drugs of  Main Class Musculoskeletal Disorders , Pain

Main Medicine Class:: Musculoskeletal Disorders , Pain  Sub Medicine Class :: Analgesics , Anti inflammatory Drugs 

Indications for Drugs ::

Rheumatoid arthritis, Ankylosing spondylitis, Post-operative pain, Dysmenorrhea, Acute gout, Acute migraine attacks, Renal colic, Cutaneous candidiasis, Mild to moderate pain, Tendonitis, Osteoarthritis (degenerative arthritis), Acute musculoskeletal disorders, Bursitis

Drug Dose ::

Adults Oral: For rheumatoid arthritis, osteoarthritis and ankylosing spondylitis The usual dose is 500-1000 mg per day taken in 2 doses at 12 hours intervals after meals. For acute gout 750 mg should be given initially, followed in 8 hours with 500 mg, and thereafter 250 mg at 12 hours intervals until the attack has passed. For dysmennorhoea 500 mg should be given initially, followed by 250 mg at 6-8 hour intervals for up to 5 days. For analgesia and acute muscular skeletal disorders 500 mg should be given initially, followed by 250 mg at 6-8 hour intervals. Children over 5 years For juvenile rheumatoid arthritis 10mg/kg/day given as 2 divided doses at 12 hour intervals. SR tablet: For rheumatoid arthritis, osteoarthritis and ankylosing spondylitis 500mg or 1000mg (500mg × 2) SR tablet once daily (morning or evening) after meals. SR tablet is also indicated after the acute condition is subsided for long term use. Naproxen suspension Adults Dosage is the same as Naproxen tablet. Children over 5 years 10 mg/kg/day given as 2 divided doses at 12 hours intervals.

Contraindication ::

Hypersensitivity. Aspirin or NSAID allergy. Perioperative pain in the setting of CABG surgery. Pregnancy (3rd trimester).

Drug Precautions ::

Pre-existing CV risk factors or disease e.g. fluid retention, CHF, hypertension. History of GI disease (bleeding or ulcers). Other forms of asthma. Hepatic impairment; closely monitor patients with any abnormal LFT. Renal impairment. Elderly. Lactation.

Drug Side Effects ::

Oedema, palpitation, dizziness, drowsiness, headache, light headedness, vertigo, pruritus, skin eruption, ecchymosis, purpura, rash, fluid retention, abdominal pain, constipation, nausea, heartburn, diarrhoea, dyspepsia, stomatitis, flatulence, gross bleeding/perforation, indigestion, ulcers, vomiting, abnormal renal function, haemolysis, anaemia, increased bleeding time, elevated LFTs, visual disturbances, tinnitus, hearing disturbances, dyspnoea, diaphoresis, thirst. Potentially Fatal: Anaphylactic/anaphylactoid reactions. Exfoliative dermatitis, Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN).

Pregnancy category ::

4

Drug Mode of Action ::  

Naproxen, a propionic acid derivative, is a prototypical NSAID. It reversibly inhibits the cyclooxygenase-1 and -2 (COX-1 and -2) enzymes, thus resulting in reduced synthesis of prostaglandin precursors. It can inhibit platelet aggregation, has anti-inflammatory, analgesic and antipyretic actions.

Drug Interactions ::

May enhance methotrexate toxicity. Reduced BP response to ACE inhibitors or angiotensin II receptor antagonists. Increased risk of serious GI events (e.g. ulcer) w/ aspirin. Increased risk of GI bleeding w/ warfarin. May reduce the natriuretic effects of furosemide or thiazide diuretics. May increase serum lithium concentrations and reduce renal lithium clearance. Delayed absorption w/ antacids, colestyramine or sucralfate. May interfere w/ the antihypertensive effects of ?-blockers (e.g. propranolol). May increase serum levels w/ probenecid.