The Brand Name NEXTRIM Has Generic Salt :: Cefuroxime 

NEXTRIM  Is From Company Nexus Priced :: Rs. 115

NEXTRIM have Cefuroxime is comes under Sub class Cephalosporins of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Cephalosporins 

Indications for Drugs ::

Pharyngitis, Acute otitis media, Lyme disease, Susceptible infections, Sinusitis, Otitis media, Skin and skin structure infections,Tonsillitis, Respiratory tract infections, Acute Maxillary Sinusitis, Urinary tract infections, Acute bacterial exacerbation of chronic bronchitis, Surgical Prophylaxis

Drug Dose ::

Adult: PO Uncomplicated UTI 125 mg twice daily. Resp tract infections 250-500 mg twice daily. Uncomplicated gonorrhoea W/ oral probenecid: 1 g as a single dose. IV Meningitis 3 g 8 hrly. IM Gonorrhoea W/ oral probenecid: 1.5 g as a single dose. IV/IM Surgical prophylaxis 1.5 g IV per-op, then 750 mg IM 8 hrly for up to 24-48 hr. Susceptible infections 750 mg 8 hrly, up to 1.5 g 6-8 hrly for severe infections. Children (above 3 months of age): 30 – 100 mg/kg/day given in 3 or 4 equally divided doses. A dose of 60mg/kg/day is appropriate for most infections. Neonate: 30 – 100 mg/kg/day given in 2 or 3 equally divided doses. Renal impairment: Patients undergoing haemodialysis should receive an additional 750-mg dose after each dialysis; those undergoing continuous peritoneal dialysis may be given 750 mg bid. CrCl (ml/min) 10-20 750 mg bid. <10 750 mg once daily. Contraindication ::

Hypersensitivity to cephalosporins.

Drug Precautions ::

Severe renal impairment; pregnancy, lactation; hypersensitivity to penicillins.

Drug Side Effects ::

Large doses can cause cerebral irritation and convulsions; nausea, vomiting, diarrhoea, GI disturbances; erythema multiforme, Stevens-Johnson syndrome, epidermal necrolysis. Potentially Fatal: Anaphylaxis, nephrotoxicity, pseudomembranous colitis.

Pregnancy category ::

2

Drug Mode of Action ::  

Cefuroxime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Drug Interactions ::

May enhance the nephrotoxic effect of strong-acting diuretics (e.g. furosemide) and aminoglycosides. May enhance the effect of oral anticoagulants. May reduce the efficacy of OCs. Probenecid prolongs the excretion of cefuroxime and elevated peak serum level.