Article Contents ::
Details About Generic Salt :: Nortriptyline
Main Medicine Class:: Nervous System Sub Medicine Class :: Anti Depressants
| 1D. ANTI-DEPRESSANTS in 1. NERVOUS SYSTEM |
| NORTRIPTYLINE |
| TRICYCLIC COMPOUND | ANTI-DEPRESSANT |
| PK: A: Rapid D: 21 L/kg (Vd) M: Hepatic E: Urine & feces |
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Indications & Dose: DEPRESSION PO Adult 25mg TID/QID, max 150mg/day Child 1-3mg/kg/day Elderly 30-50mg in divided doses | NEUROPATHIC PAIN PO Adult 10-25mg HS, max 25mg/day | NOCTURNAL ENURESIS PO Child 10-20mg/day, max 40mg/day | SMOKING CESSATION PO Adult Initially 25mg/day, 75-100mg/day 10-28 days before to quit, continue 12 Wks |
| Contra: Hypersensitivity, use of MAO inhibitors within 14 days, MI
Precautions: History of epilepsy, hepatic/renal impairment, elderly, thyroid disease, pheochromocytoma, glaucoma, avoid abrupt withdrawal, concurrent electroconvulsive therapy ADR: Serious: ECG changes, arrhythmias, postural hypotension, thrombocytopenia, hypersensitivity reactions, mania, hyponatremia, blood disorders, convulsions, movement disorders, acidosis, respiratory depression, blurred vision, Others: headache, anxiety, dry mouth, constipation, nausea, fever, restlessness, weight gain, sedation, confusion, diarrhea DDI: Serious Guanethidine/Clonidine antihypertensive effects get abloished or reduced by drug, Bupropion increases drug level (confusion, lethargy and unsteadiness), Cimetidine increases plasma drug level, Noradrenaline/Adrenaline increases risk of HTN & arrhythmias, Disopyramide/Amiodarone/Sotalol increases risk of ventricular arrhythmias, Quinidine reduces drug clearance, Barbiturates reduces drug level & lowers convulsive threshold level, Dextropropoxyphene rises serum drug level Others Terbinafine/Fluconazole increases drug levels, Carbamazepine reduces drug levels Diet: With/without food Monitor: BP, ECG & suicidal thoughts |