The Brand Name ORALEXINE Has Generic Salt :: Cephalexin 

ORALEXINE  Is From Company Kentreck Priced :: Rs. 59

ORALEXINE have Cephalexin is comes under Sub class Cephalosporins of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Cephalosporins 

Indications for Drugs ::

Pneumonia, Otitis media, Bacterial endocarditis, Streptococcal pharyngitis, Cellulitis, Respiratory tract infections, Urinary tract infections, Bone and Joint Infections, Genitourinary tract infections, Acute prostatitis

Drug Dose ::

Adults 1 to 4 g/day in divided doses. Usual dose is 250 mg every 6 hours. Streptococcal pharyngitis, skin and skin structure infections, uncomplicated cystitis in patients>15 years 500 mg every 12 hours. May need larger doses for more severe infections or less susceptible organisms. Children 25 to 50 mg/kg/day in divided doses. For streptococcal pharyngitis in patients >1year old and for skin and skin structure infections, divide total daily dose and give every 12 hours. In sever infections, double the dose. Otitis media: 75 to 100 mg/kg/day in 4 divided doses. beta-hemolytic streptococcal infections: Continue treatment for at least 10 days. Renal impairment: CrCl (ml/min) 40-50 Max: 3 g daily. 10-40 Max: 1.5 g daily. <10 Max: 750 mg daily. Contraindication ::

Hypersensitivity to cephalosporins.

Drug Precautions ::

Hypersensitivity to penicillins; pseudomembranous colitis; renal failure; pregnancy and lactation.

Drug Side Effects ::

Pain at inj site; hypersensitivity; GI disturbances; eosinophilia, neutropenia, leucopenia, thrombocytopenia. Potentially Fatal: Anaphylactic reactions; nephrotoxicity.

Pregnancy category ::

2

Drug Mode of Action ::  

Cefalexin binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Drug Interactions ::

Concurrent use w/ metfromin may result to fatal lactic acidosis. May enhance the anticoagulant effect of vit K antagonists (e.g. warfarin). Increased risk of nephrotoxicity w/ potent diuretics (e.g. ethacrynic acid, furosemide) and other potentially nephrotoxic antibiotics (e.g. aminoglycosides, polymyxin, colistin). Prothrombin time may be prolonged when used concomitantly w/ oral anticoagulants. May reduce the effects of OCs. Hypokalaemia may result from concomitant use of cefalexin and cytotoxic drugs for leukaemia. Uricosuric drugs (e.g. probenecid) may suppress renal excretion, resulting to increased plasma levels of cefalexin. May diminish the therapeutic effect of Na picosulfate, BCG and typhoid vaccine. May reduce serum level w/ multivitamins/minerals.