The Brand Name OXYMETRIN Has Generic Salt :: Ergometrine 

OXYMETRIN  Is From Company German R. Priced :: Rs. 17

OXYMETRIN have Ergometrine is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Postpartum and post-abortion bleeding, 3rd stage of labour, Uterine bleeding, Postpartum haemorrhage

Drug Dose ::

Adult: PO Post-partum and post-abortion bleeding 0.2-0.4 mg 2-4 times/day until danger of uterine atony and haemorrhage has passed. Max duration: 1 wk postpartum. IV Excessive uterine bleeding 200 mcg over at least 1 min, followed by oral doses of 200-400 mcg 2-4 times/day until the danger of atony or haemorrhage has passed. IM Active management of 3rd stage of labour 500 mcg w/ oxytocin after delivery of the anterior shoulder of the infant or immediately after delivery. Postpartum haemorrhage 200 mcg, may repeat in severe bleeding 2-4 hrly if needed.

Contraindication ::

Pregnancy, 1st and 2nd stage of labour, patients with preeclampsia, eclampsia or threatened spontaneous abortion; porphyria.

Drug Precautions ::

Breech and abnormal foetal presentation; hypertension; chronic anaemia; hepatic, renal, respiratory or cardiac impairment; toxemia; lactation; hypocalcaemia. Monitor BP, pulse and uterine response.

Drug Side Effects ::

Nausea, vomiting, abdominal pain, diarrhoea; headache, dizziness; tinnitus; chest pain, palpitation, bradycardia, transient hypertension and other cardiac arrhythmias; dyspnoea, sometimes rashes, shock. Potentially Fatal: MI, pulmonary oedema.

Pregnancy category ::

5

Drug Mode of Action ::  

Ergometrine causes contraction of the uterine muscle. At low doses, there is an increase in frequency and amplitude of contractions while at higher doses, the basal tone of the uterus is increased. Ergometrine also causes vasoconstriction of peripheral and cerebral vessels.

Drug Interactions ::

Halothane causes relaxation of uterine muscle and may interfere with ergometrine action. Enhanced uterotonic effect with prostaglandins and oxytocin. Concurrent admin with CYP3A4 inhibitors may lead to vasospasm, cerebral ischaemia and/or ischaemia of extremities. Potentially Fatal: Enhanced vasoconstrictive effects with sympathomimetics and other vasoconstrictors.