The Brand Name PEPLER Has Generic Salt :: Propantheline 

PEPLER  Is From Company Sun Priced :: Rs. 5.2

PEPLER have Propantheline is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Hyperhidrosis, Peptic ulcer, Urinary incontinence, GI tract spasm, Adult enuresis

Drug Dose ::

Oral Adjunct in peptic ulcer Adult: 15 mg tid and 30 mg at bedtime. Doses up to 120 mg daily may be needed. Child: For relief of GI spasm: 1 mth – 12 yr: 300 mcg/kg (max 15 mg), given 3-4 times daily. Elderly: 7.5 mg tid. May increase to a max of 30 mg tid. Gastrointestinal tract spasm Adult: 15 mg tid and 30 mg at bedtime. Doses up to 120 mg daily may be needed. Child: For relief of GI spasm: 1 mth – 12 yr: 300 mcg/kg (max 15 mg), given 3-4 times daily. Elderly: 7.5 mg tid. May increase to a max of 30 mg tid. Urinary incontinence Adult: 15-30 mg bid/tid. Adult enuresis Adult: 15-30 mg bid/tid. Hyperhidrosis Adult: 15-30 mg bid/tid.

Contraindication ::

Glaucoma, obstructive diseases of GI or urinary tract, severe ulcerative colitis or toxic megacolon, intestinal atony, hiatus hernia associated with reflux oesophagitis, unstable cardiovascular adjustment in acute bleeding, prostatic enlargement, myasthenia gravis, paralytic ileus, pyloric stenosis, angle-closure glaucoma.

Drug Precautions ::

Hyperthyroidism, congestive heart failure, coronary heart disease, cardiac arrhythmias, acute MI, cardiac insufficiency, hypertension. Pregnancy and lactation; elderly. Patients with fever, diarrhoea, GI reflux disease or ulcerative colitis. Hepatic or renal impairment. Increased risk of fever or heat stroke in patients exposed to high environmental temperature. Caution when used in patients with Down’s syndrome.

Drug Side Effects ::

Dry mouth, thirst, difficulty in swallowing, skin dryness, flushing, reduced sweating, heat stroke, constipation, nausea and vomiting. Pupil dilatation with loss of accomodation and increased sensitivity to light; increased intra-ocular pressure. Bradycardia followed by tachycardia, arrhythmias and palpitations. Glaucoma, urinary hesitancy and retention, orthostatic hypotension especially in elderly. Potentially Fatal: Toxic megacolon due to preexisting ulcerative colitis.

Pregnancy category ::

3

Drug Mode of Action ::  

Propantheline bromide is a quarternary ammonium antimuscarinic with antisecretory and antispasmodic effects.

Drug Interactions ::

Additive anticholinergic effect with MAOIs, TCAs, phenothiazines, antihistamines and disopyramide. Delayed gastric emptying causes delayed absorption of other drugs. May antagonise the GI effects of domperidone, cisapride and metoclopramide. May reduce absorption of ketoconazole and levodopa. May increase absorption of nitrofurantoin. May increase serum levels of digoxin. May reduce effects of haloperidol and sublingual tablets of nitrates. May antagonise effects of parasympathomimetics.