The Brand Name PHYLIN-1 Has Generic Salt :: Theophylline 

PHYLIN-1  Is From Company Obsurge Priced :: Rs. 39.5

PHYLIN-1 have Theophylline is comes under Sub class Drugs For Asthma,COPD,ARDS of  Main Class Respiratory System

Main Medicine Class:: Respiratory System  Sub Medicine Class :: Drugs For Asthma,COPD,ARDS 

Indications for Drugs ::

Asthma, Chronic obstructive pulmonary disease, Bronchospasm, Apnoea

Drug Dose ::

Adult: PO: usually controlled release tablet 12 hourly or as directed by the physicians. 10-15mg/Kg/day, 2 times daily. Child: 1-6 months: 10mg/Kg/day, 6 m-1 year: 15mg/Kg/day, 1-9 years: 24mg/Kg/day, 10-l6 years: 18mg/Kg/day, in divided doses.

Contraindication ::

Hypersensitivity to xanthine derivatives, porphyria.

Drug Precautions ::

Smoking and alcohol consumption can increase the clearance of Theophylline and a higher dosage may be necessary.Careful monitoring is recommended for patients with congestive heart failure, chronic alcoholism, hepatic dysfunction or viral infections as they may have lower total clearance of Theophylline which could lead to higher than normal plasma levels.Caution should be exercised in patients with hyperthyroidism, cardiac arrhythmia, hypertension or other cardiovascular diseases.

Drug Side Effects ::

Nausea, vomiting, abdominal pain, diarrhoea, headache, insomnia, dizziness, anxiety, restlessness, tremor, palpitations.Potentially Fatal: Convulsions, cardiac arrhythmias, hypotension and sudden death after too rapid IV inj.

Pregnancy category ::

3

Drug Mode of Action ::  

Theophylline competitively blocks phosphodiesterase which increases cAMP tissue concentrations causing bronchodilatation, diuresis, CNS and cardiac stimulation, and gastric acid secretion.

Drug Interactions ::

Other xanthines. Theophylline clearance reduced by high dose allopurinol, some antiarrhythmics, cimetidine, disulfiram, propranolol, methotrexate, aciclovir, mexiletine, pentoxifylline, tacrine, ticlopidine, fluvoxamine, interferon-?, macrolide antibiotics, quinolones, oral contraceptives, thiabendazole and viloxazine. Theophylline clearance increased by phenytoin, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, aminoglutethimide, barbiturates, ipriflavone, cigarette smoking. Concurrent use decreased lithium, alprazolam levels. Increased risk of arrhythmias with ephedrine, sympathomimetic, general anaesthetics. Increased heart rate with tadalafil.