The Brand Name PIPRACIL Has Generic Salt :: Piperacillin 

PIPRACIL  Is From Company Wyeth Priced :: Rs. 262

PIPRACIL have Piperacillin is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Septicaemia, Nosocomial pneumonia

Drug Dose ::

Intravenous Nosocomial pneumonia Adult: Initial dose: 4.5 g (piperacillin 4 g and tazobactam 0.5 g) every 6 hr for 7-14 days. When used empirically, combination with an aminoglycoside or antipseudomonal fluoroquinolone is recommended. May be given via infusion over 30 minutes. If Pseudomonas aeruginosa is not isolated, may discontinue aminoglycoside. Child: 2-8 mth: 80 mg of piperacillin/kg every 8 hr; >9 mth and >40 kg: 100 mg of piperacillin/kg every 8 hr. Severe infections Adult: 3.375 g (piperacillin 3 g and tazobactam 0.375 g) every 6 hr for 7-10 days. May be given via infusion over 30 minutes. Renal impairment: For haemodialysis, admin an additional dose of 0.75 g after each dialysis session on haemodialysis days. CrCl (ml/min) >40 3.375 g every 6 hr 20-40 2.25 g every 6 hr <20 2.25 g every 8 hr Haemodialysis 2.25 g every 12 hr CAPD 2.25 g every 12 hr Contraindication ::

Hypersensitivity.

Drug Precautions ::

Pregnancy and lactation, pseudomembranous colitis. Assess hematopoietic function periodically. Perform periodic electrolyte determinations in patients with low K reserves. Increased risk of fever and rash in patients with cystic fibrosis. Increased risk of bleeding manifestations. Prolonged treatment may increase risk of superinfections. Convulsions or neuromuscular excitability may occur when high doses are used, especially in renally impaired patients. Renal impairment.

Drug Side Effects ::

Diarrhoea, skin rashes, occasionally platelet mediated bleeding, rigors, malaise, ulcerative stomatitis. Inj-site reactions such as pain, erythema, induration and thrombophlebitis. Potentially Fatal: Serious, anaphylactic reactions.

Pregnancy category ::

2

Drug Mode of Action ::  

Piperacillin has an antimicrobial activity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against gm+ve organisms eg E. faecalis and B. fragilis. Tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. In combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria.

Drug Interactions ::

Interacts w/ high doses of heparin, oral anticoagulants or other drugs that affect blood coagulation or thrombocyte function. Prolongs the neuromuscular blockade of vecuronium and non-depolarising muscle relaxants. Prolongs half-lives w/ probenecid. Increased risk of methotrexate toxicity.