The Brand Name PROFASI IU Has Generic Salt :: Human 

PROFASI IU  Is From Company Serum Inst. Priced :: Rs. 874.26

PROFASI IU have Human is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Postexposure prophylaxis of Rabies

Drug Dose ::

Recommended Dose: Adults and Children: 40 IU/kg of body weight. However, for children, particularly in the case of multiple wounds, it has been proposed to dilute the dose 2-3 times in a 0.9% sodium chloride solution to obtain a sufficient quantity of equine rabies immune globulin to infiltrate the wound(s) correctly. It must be injected slowly by the IM route. If anatomically feasible, as much as possible of the dose should be infiltrated around and into the wounds. The remainder of the dose should be administered IM (into the gluteal region) in a single injection. As a general rule, 1 IU of Factor IX activity per kg can be expected to increase the circulating level of Factor IX by 1% [IU/dL] of normal.

Contraindication ::

Known history of allergic symptoms to horse proteins.

Drug Precautions ::

Administered intravenously at a rate that will permit observation of the patient for any immediate reaction. Rates of infusion of up to 225 IU per minute have been regularly tolerated with no adverse reactions. If any reaction takes place that is thought to be related to the administration , the rate of infusion should be decreased or the infusion stopped, as dictated by the response of the patient. The infusion should be stopped promptly and appropriate countermeasures and supportive therapy should be administered should evidence of an acute hypersensitivity reaction be observed. Patients known to have major deletion mutations of the factor IX gene may be at increased risk for inhibitor formation and acute hypersensitivity reactions.

Drug Side Effects ::

Do not administer the vaccine IV due to the risk of shock ie, sudden collapse with drop in blood pressure.

Pregnancy category ::

3

Drug Mode of Action ::  

Rabies immunoglobulins provide passive immunity to rabies. 2 types of immunoglobulin are available namely, human rabies immunoglobulin (HRIG) and purified equine rabies immunoglobulin (ERIG). HRIG is prepared from the plasma of human donors hyperimmunised with rabies vaccine and is preferred over ERIG.

Drug Interactions ::

Decreased response to live virus vaccine (e.g. measles, mumps, rubella and varicella), admin at least 4 mth after human rabies immunoglobulin admin.