The Brand Name PROLINE Has Generic Salt :: Lorazepam 

PROLINE  Is From Company SHINE PH. Priced :: Rs. 11.8

PROLINE have Lorazepam is comes under Sub class Anxiolytics of  Main Class Nervous System

Main Medicine Class:: Nervous System  Sub Medicine Class :: Anxiolytics 

Indications for Drugs ::

Anxiety, Status epilepticus, Sedation, psychosomatic, organic or psychotic illness, insomnia associated with anxiety, nervousness, restlessness, nausea and vomiting related to chemotherapy and anticonvulsants, and as a premedicant before dental or general surgery or prior to investigative procedures where there may be discomfort.

Drug Dose ::

Adult: PO Anxiety 1-6 mg/day in 2 or 3 divided doses, up to 10 mg/day. Insomnia associated w/ anxiety 1-4 mg/day at bedtime. Prophylaxis of nausea and vomiting associated with cytotoxic therapy For moderately emetogenic chemotherapy: May add 1-2 mg to the antiemetic therapy. Premed in surgery 2-3 mg the night before operation, then a smaller dose in the morning if needed. For elderly or debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended, to be adjusted as needed and tolerated. IV Status epilepticus 4 mg, repeat once after 10-15 mins if needed. Sedation in critical care 0.02-0.06 mg/kg 2-6 hrly as inj or 0.01-0.1 mg/kg/hr as continuous infusion. IV/IM Acute anxiety 25-30 mcg/kg 6 hrly if needed. Premed in surgery 50 mcg/kg, to be given 30-45 minutes before the operation if given via IV inj or 1-1.5 hr before operation if given via IM inj.

Contraindication ::

Severe hepatic impairment; respiratory depression; acute narrow-angle glaucoma; pregnancy and lactation.

Drug Precautions ::

Hepatic and renal dysfunction; pulmonary insufficiency; myasthenia gravis; may impair ability to drive or operate machinery; elderly or debilitated patients.

Drug Side Effects ::

Drowsiness, headache, dizziness, confusion; blurred vision; nausea; weakness; unsteadiness.Potentially Fatal: Respiratory depression.

Pregnancy category ::

4

Drug Mode of Action ::  

Lorazepam is a short acting benzodiazepine. It increases neuronal membrane permeability to Cl ions by binding to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron w/in the CNS (including the limbic system, reticular formation) and enhancing the GABA inhibitory effects resulting in hyperpolarisation and stabilisation.

Drug Interactions ::

Drugs that affect the CNS (e.g. barbiturates, phenothiazines, antidepressants, MAOIs) may have additive CNS effects. Scopolamine may increase sedation, hallucinations and irrational behaviour. May reduce sedative and anxiolytic effect w/ caffeine, theophylline or aminophylline. May increase plasma level w/ Na valproate or probenecid.