Article Contents ::
Details About Generic Salt :: Quinine
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 13J. ANTI-MALARIALS in 13. ANTI-INFECTIVES |
| QUININE |
| 4-METHANOLQUINOLINE DERIVATIVE | ANTI-MALARIAL, SKELETAL MUSCLE RELAXANT |
| PK: A: Rapid D: 0.9 L/kg (child), 2.5-7.1 L/kg (adults) M: Hepatic E: Urine |
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Indications & Dose: MALARIA PO Adult As sulfate or hydrochloride or dihydrochloride: 600mg q8h 7 days Child 10mg/kg q8h 7 days | NOCTURNAL LEG CRAMPS PO Adult 200-300mg HS (as sulfate or bisulfate) Child 10mg/kg body weight q8h 7 days | PLASMODIUM FALCIPARUM MALARIA Complicated/Severe IV Adult Loading dose 20mg/day (as dihydrochloride), max 1.4g over 4h with maintenance infusions after 8h (calculated from the start of previous infusion) |
| Contra: Hypersensitivity, history of hypersensitivity reactions, G6PD deficiency, optic neuritis, tinnitus, nocturnal leg cramps
Precautions: Myasthenia gravis, history of arrhythmia, CVD ADR: Serious: atrial fibrillation, AV block, cardiac arrest, hypotension, irregular rhythm, QT prolongation, tachycardia, seizure, blood disorders, SJS, TEN, erythema multiforme, hepatitis, pulmonary edema, Others: tinnitus, myalgia, dyspnea, hypoglycemia, GI irritation, nausea, vomiting, dermatitis, cutaneous rash, confusion, dizziness, headache DDI: Serious Aluminum Hydroxide Gel delays/decreases drug absorption, Rifampicin leads to subtherapeutic drug level, Digoxin toxicity occurs Diet: With/without food Monitor: signs & symptoms of hypersensitivity reaction, cinchonism, CBC, LFT |