Article Contents ::
Details About Generic Salt :: Raloxifene
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Drugs affecting Bone Metabolism
| 8I. DRUGS AFFECTING BONE METABOLISM in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| RALOXIFENE |
| NON STEROIDAL BENZOTHIOPHENE DERIVATIVE | SELECTIVE ESTROGEN RECEPTOR MODULATOR |
| PK: A: Rapid D: 2348L/kg M: Hepatic E: Feces & urine |
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Indications & Dose: INVASIVE BREAST CANCER RISK REDUCTION PO Adult 60mg OD 5 yr in females | OSTEOPOROSIS PO Adult 60mg OD in females |
| Contra: hypersensitivity, history of/current venous thromboembolic disorders
Precautions: hepatic/renal impairment, CVD, hypertriglyceridamia, prolonged immobilization ADR: Serious: hot flashes, breast pain, vaginal bleeding, bronchitis, peripheral edema, arthralgia, muscle spasm, flu syndrome, venous thromboembolism, endometrial disorder, myalgia, Others: diaphoresis, insomnia, weight gain, uterine disorder, pneumonia, sinusitis DDI: Serious Warfarin decreases PT, Levothyroxine increases TSH level & symptoms of hypothyroidism, Colestyramine/Colestipol reduces drug absorption Diet: Without food Monitor: BMD, lipid profile, diagnostic measures, endometrial sampling, vaginal bleeding |
