Article Contents ::
Details About Generic Salt :: Silodosin
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 10C. DRUGS FOR PROSTATE DISORDERS in 10. GENITO-URINARY SYSTEM |
| SILODOSIN |
| ALPHA1-ADRENERGIC RECEPTOR BLOCKER | DRUG FOR BPH |
| PK: D: 49.5L (Vd) M: Hepatic E: Feces & urine |
|
Indications & Dose: BENIGN PROSTATIC HYPERPLASIA PO Adult 8mg/day |
| Contra: Hypersensitivity, severe renal impairment, severe hepatic impairment, Concomitant strong CYP3A4 inhibitors/P-glycoprotein inhibitors
Precautions: mild-to-moderate hepatic impairment, elderly (risk of hypotension), women/children, concomitant use of antihypertensives ADR: Serious: Retrograde ejaculation, Others: Diarrhea, headache, insomnia, dizziness, orthostatic hypotension, nasopharyngitis, nasal congestion, sinusitis DDI: Others Carbamazepine/Aspirin/Clotrimazole decrease silodosin effects, Cyclosporine/Carbidopa+Levodopa/Indinavir increase silodosin effects, Alfuzosin increases antihypertensive activity, Mefloquine increases silodosin effects leads to life threatening interaction Diet: with food |