Article Contents ::
Details About Generic Salt :: Somatropin
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Pituitary Hormones,Gonadotropins
| 8B. PITUITARY HORMONES/GONADOTROPINS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| SOMATROPIN |
| POSTERIOR PITUITARY HORMONE | GROWTH HORMONE |
| PK: A: Well absorbed (IM, SC) D: 1 L/kg M: Hepatic & renal E: Urine |
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Indications & Dose: GROWTH HORMONE DEFICIENCY SC Adult 6µg/kg (0.018U/kg), then increased according to patient response, max 12.5µg/kg/day Child 25-35µg/kg/day (0.07-0.1U/kg) | GROWTH RETARDATION SC Child Due to CRF: 45-50µg/kg/day, Children with growth retardation who were born small for gestational age: 480µg/kg weekly divided into 6 or 7 doses | HIV-ASSOCIATED WASTING/CACHEXIA SC Adult 100µg/kg/day, max 6mg/day | IDIOPATHIC SHORT STATURE SC Child 300-470µg/kg divided into 6 or 7 doses/wk | NOONAN SYNDROME SC Child 66µg/kg/day | PRADER-WILLI SYNDROME SC Child 35µg/kg/day, max 2.7mg | SHORT BOWEL SYNDROME SC Adult 100µg/kg/day max 8mg/day 4 wk | TURNER’S SYNDROME SC Child 45-50µg/kg (0.14U/kg) |
| Contra: Hypersensitivity, respiratory impairment, prader-willi syndrome, intracranial tumor, multiple accidental trauma, active neoplasm, diabetic retinopathy, epiphyses
Precautions: Turner syndrome, DM, hypothyroidism, obesity, hypopituitarism ADR: Serious: benign intracranial HTN, hypoglycemia, ear disorders, ketosis, leukemia, arthralgia, seizure, psoriasis exacerbation, scoliosis, edema, flu-like syndrome, myalgia, paresthesia, hypothyroidism, Others: hyperglycemia, rhinitis, glucose intolerance, RTI, headache, weakness, rash DDI: Serious Corticosteroids inhibits growth promoting effects of drug Monitor: TSH, serum phosphorus, alkaline phosphatase, blood glucose, X-rays, urine test, somatomedin C levels, funduscopic examinations |