Article Contents ::
Details About Generic Salt :: Tolvaptan
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 10E. DRUGS FOR ELECTROLYTE DISTURBANCES in 10. GENITO-URINARY SYSTEM |
| TOLVAPTAN |
| BENZAZEPINE DERIVATIVE | VASOPRESSIN RECEPTOR V2 ANTAGONIST |
|
Indications & Dose: EUVOLEMIC/HYPERVOLEMIC HYPONATREMIA PO Adult 15mg OD, dosage may be increased to 30mg OD at an interval of at least 24h, max 60mg OD to achieve serum sodium concentration |
| Contra: Patients who require urgent intervention to acutely raise serum sodium concentration, inability of the patient to sense or appropriately respond to thirst, hypovolemic hyponatremia, anuria, concomitant use of potent inhibitors of CYP450 isoenzyme
Precautions: Avoid fluid restrictions during the first 24 h of therapy, concomitant use with hypertonic sodium chloride is not recommended, safety and efficacy not established in children <18 years, advise that may continue to take drinking fluids in response to thirst ADR: Serious: Osmotic demyelination, dysarthria, mutism, lethargy, dysphagia, spastic quadriparesis, GI bleeding in patients with cirrhosis, dehydration and hypovolemia, hyperkalemia, Others: thirst, dry mouth, polyuria, asthenia, constipation, hyperglycemia, pyrexia, anorexia DDI: Serious Ciclosporin increases drug levels, Diuretics increases the risk of dehydration and hypovolemia with the concurrent use of drug, Lovastatin levels modestly increases by drug, Rifampicin/CYP3A4 Inducers reduces the drug exposure, Potassium-sparing diuretics/ACEIs slightly increases the risk of hyperkalemia with drug Monitor: Serum sodium concentration, Serum potassium concentration,neurologic status |