Details About Overdose or Poisoning Generic Salt :: Digoxin Specific Antibodies Digoxin-Specific Antibodies Drug Pharmacology :: I. Pharmacology. Digoxin-specificantibodies are produced in immunized sheep and have a high bindingaffinity for digoxin and, to a lesser extent, digitoxin and othercardiac glycosides. The Fab fragments used to treat poisoning arederived by cleaving the whole...
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Details About Overdose or Poisoning Generic Salt :: Hydroxocobalamin Hydroxocobalamin Drug Pharmacology :: I. Pharmacology. Hydroxocobalaminand cyanocobalamin are synthetic forms of vitamin B12 that are used forthe treatment of pernicious anemia. Hydroxocobalamin has beenrecognized as an antidote for cyanide poisoning for over 45 years.Hydroxocobalamin immediately exchanges its hydroxyl group with freecyanide in the...
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Details About Overdose or Poisoning Generic Salt :: Ethanol Ethanol Drug Pharmacology :: I. Pharmacology. Ethanol(ethyl alcohol) acts as a competitive substrate for the enzyme alcoholdehydrogenase, preventing the metabolic formation of toxic metabolitesfrom methanol or ethylene glycol. Blood ethanol concentrations of 100mg/dL, or at least a 1:4 molar ratio of ethanol to...
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Details About Overdose or Poisoning Generic Salt :: Magnesium Magnesium Drug Pharmacology :: I. Pharmacology./b> Magnesiumis the fourth most common cation in the body and is the second mostabundant intracellular cation after potassium. Magnesium plays anessential role as an enzymatic cofactor in a number of biochemicalpathways, including energy production from adenosine...
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Details About Overdose or Poisoning Generic Salt :: Morphine Morphine Drug Pharmacology :: I. Pharmacology. Morphineis the principal alkaloid of opium and is a potent analgesic andsedative agent. In addition, it decreases venous tone and systemicvascular resistance, resulting in reduced preload and afterload.Morphine is absorbed variably from the GI tract and usually...
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Details About Overdose or Poisoning Generic Salt :: Phenobarbital Phenobarbital Drug Pharmacology :: I. Pharmacology. Phenobarbitalis a barbiturate commonly used as an anticonvulsant. Because of thedelay in onset of the therapeutic effect of phenobarbital, diazepam(see Benzodiazepines [Diazepam, Lorazepam, and Midazolam]) is usuallythe initial agent for parenteral anticonvulsant therapy. After an oraldose of...
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Details About Overdose or Poisoning Generic Salt :: Inamrinone, Formerly Amrinone Inamrinone (Formerly Amrinone) Drug Pharmacology :: I. Pharmacology. Inamrinoneis a positive inotropic agent with vasodilator activity. It is not abeta-adrenergic receptor agonist, and its exact mechanism of action isunknown. It appears to work by inhibiting myocardial cellphosphodiesterase activity, thereby increasing cellular concentrationsof...
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Details About Overdose or Poisoning Generic Salt :: Glucose Glucose Drug Pharmacology :: I. Pharmacology. Glucoseis an essential carbohydrate that is used as a substrate for energyproduction within the body. Although many organs use fatty acids as analternative energy source, the brain is totally dependent on glucose asits major energy source; thus,...
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Details About Overdose or Poisoning Generic Salt :: Metoclopramide Metoclopramide Drug Pharmacology :: I. Pharmacology. Metoclopramideis a dopamine antagonist with antiemetic activity at the chemoreceptortrigger zone. It also accelerates GI motility and facilitates gastricemptying. The onset of effect is 1–3 minutes after intravenousadministration, and therapeutic effects persist for 1–2 hours after asingle...
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Details About Overdose or Poisoning Generic Salt :: Leucovorin Calcium Leucovorin Calcium Drug Pharmacology :: I. Pharmacology. Leucovorin(folinic acid or citrovorum factor) is a metabolically functional formof folic acid. Unlike folic acid, leucovorin does not require reductionby dihydrofolate reductase, and therefore it can participate directlyin the one-carbon transfer reactions necessary for purine...
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