Details About Overdose or Poisoning Generic Salt :: Thiamine, Thiamin, Vitamin B1 Thiamine (Thiamin, Vitamin B1) Drug Pharmacology :: I. Pharmacology. Thiamine (vitamin B1)is a water-soluble vitamin that acts as an essential cofactor forvarious pathways of carbohydrate metabolism. Thiamine also acts as acofactor in the metabolism of glyoxylic acid (produced in ethyleneglycol...
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Details About Overdose or Poisoning Generic Salt :: Esmolol Esmolol Drug Pharmacology :: I. Pharmacology. Esmololis a short-acting, IV, cardioselective beta-adrenergic blocker with nointrinsic sympathomimetic or membrane-depressant activity. In usualtherapeutic doses, it causes little or no bronchospasm in patients withasthma. Esmolol produces peak effects within 6–10 minutes ofadministration of an intravenous bolus....
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Details About Overdose or Poisoning Generic Salt :: Pyridoxine, Vitamin B6 Pyridoxine (Vitamin B6) Drug Pharmacology :: I. Pharmacology. Pyridoxine (vitamin B6)is a water-soluble B-complex vitamin that acts as a cofactor in manyenzymatic reactions. Overdose involving isoniazid or othermonomethylhydrazines (eg, Gyromitra mushrooms) may causeseizures by interfering with pyridoxine utilization in the brain,...
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Details About Overdose or Poisoning Generic Salt :: Botulinum Antitoxin Botulinum Antitoxin Drug Pharmacology :: I. Pharmacology. Botulinumantitoxin contains concentrated equine-derived antibodies directedagainst the toxins produced by the various strains of Clostridium botulinum(A, B, and E). The antitoxin is currently available in the bivalent (A,B) and monovalent (E) forms. The monovalent (E)...
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Details About Overdose or Poisoning Generic Salt :: Calcium Calcium Drug Pharmacology :: I. Pharmacology./b> Calciumis a cation that is necessary for the normal functioning of a varietyof enzymes and organ systems, including muscle and nerve tissue.Hypocalcemia, or a blockade of calcium’s effects, may cause musclecramps, tetany, and ventricular fibrillation. Antagonism...
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Details About Overdose or Poisoning Generic Salt :: Cyproheptadine Cyproheptadine Drug Pharmacology :: I. Pharmacology. Cyproheptadineis a first-generation, histamine-1 blocker with nonspecific serotonin(5-HT) antagonism. The administration of cyproheptadine to patientswith serotonin syndrome appears to antagonize excessive stimulation of5-HT1A and 5-HT2 receptors, resulting in improvements in clinicalsymptoms (based on anecdotal case reports). Drug...
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Details About Overdose or Poisoning Generic Salt :: Nitroprusside Nitroprusside Drug Pharmacology :: I. Pharmacology. Nitroprussideis an ultra-short-acting titratable parenteral hypotensive agent thatacts by directly relaxing vascular smooth muscle as a nitric oxidedonor. Both arterial dilation and venous dilation occur; the effect ismore marked in patients with hypertension. A small increase in...
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Details About Overdose or Poisoning Generic Salt :: Isoproterenol Isoproterenol Drug Pharmacology :: I. Pharmacology. Isoproterenolis a catecholamine-like drug that stimulates beta-adrenergic receptors(beta-1 and -2). Its pharmacologic properties include positiveinotropic and chronotropic cardiac effects, peripheral vasodilation,and bronchodilation. Isoproterenol is not absorbed orally and showsvariable and erratic absorption from sublingual and rectal sites....
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Details About Overdose or Poisoning Generic Salt :: Phentolamine Phentolamine Drug Pharmacology :: I. Pharmacology. Phentolamineis a competitive presynaptic and postsynaptic alpha-adrenergic receptorblocker that produces peripheral vasodilation. By acting on both venousand arterial vessels, it decreases total peripheral resistance andvenous return. It also may stimulate beta-adrenergic receptors, causingcardiac stimulation. Phentolamine has a...
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Details About Overdose or Poisoning Generic Salt :: Insulin Insulin Drug Pharmacology :: I. Pharmacology./b> Insulin, a hormone secreted by the beta cells of the pancreas, promotescellular uptake of glucose into skeletal and cardiac muscles andadipose tissue. Insulin shifts potassium intracellularly. The mechanism by which insulin-dextrose (hyperinsulinemia-euglycemia)therapy improves inotropy and increases...
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