Indications & Dose: ASYMPTOMATIC VENTRICULAR DYSFUNCTION PO Adult 2.5mg BID, titrated as tolerated max 20mg/day | HEART FAILURE PO Adult Initially 2.5mg OD/BID (usual range 5-40mg/day in 2 divided doses), gradually increase at 1-2 wk intervals, target dose 10-20mg BID | HYPERTENSION PO Adult Initially 2.5-5mg/day increase as required at 1-2 wk interval, usual dose range 2.5-40mg/day in 1-2 divided doses | IV Adult 1.25mg/dose over 5 min q6h. Reduce the dose to 0.625mg if patient is on diuretic therapy, may repeat the dose after 1h if required & administer 1.25mg q6h. Once adequate response is achieved administer 0.625mg q6h

Precautions: CVD, collagen vascular disease, hypertrophic cardiomyopathy, renal artery stenosis, renal impairment, before, during/immediately after major surgery

ADR: Serious: Hypotension, syncope, orthostatic hypotension, orthostasis, Others: Headache, dizziness, fatigue, bronchitis, cough, dyspnea, abdominal pain, worsening of renal function, diarrhea, anorexia

DDI: Serious CNS Depressants/Albumin acute hypotension, Probenecid decreases drug renal clearance, Antidiabetics increases risk of hypoglycaemia, NSAIDs increases risk of renal impairment & hyperkalemia, Azathioprine leads to anemia, Sirolimus leads to angioedema, Interferons leads to severe granulocytopenia, Lithium levels raises & its toxicity, Aspirin reduces antihypertensive efficacy of drug

Diet: With/without food

Monitor: BP, SeCr, CBC