Details About Generic Salt ::  Nelfinav

Main Medicine Class:: Antiviral   

Class: Antiviral


Drugs Class ::

 Action Inhibits human immunodeficiency virus (HIV) protease, the enzyme required to form functional proteins in HIV-infected cells.

Indications for Drugs ::

 Indications Treatment of HIV infection. May be given in combination with nucleoside analogues (eg, zidovudine) or as monotherapy.

Drug Dose ::


ADULTS & CHILDREN > 13 YR: PO 750 mg tid in combination with nucleoside analogs. CHILDREN 2 to 13 YR: PO 20 to 30 mg/kg/dose tid.

Contraindication ::

 Contraindications Hypersensitivity to nelfinavir or any component of the product. Concomitant therapy with amiodarone, astemizole, cisapride, ergot-derivatives, quinidine, rifampin and terfenadine. Concurrent therapy with alprazolam, clorazepate, diazepam, estazolam, flurazepam, midazolam, triazolam and zolpidem.

Drug Precautions ::


Pregnancy: Category B. Lactation: Undetermined. HIV-infected mothers should not breastfeed their infants. Children: Safety and efficacy not established for children < 2 yr. Hepatic function impairment: Use caution; decreased nelfinavir clearance may occur. Diabetes: New onset diabetes and exacerbation of pre-existing diabetes mellitus has been reported in postmarking surveillance. Hemophilia: There have been reports of increased bleeding, including skin hematomas and hemarthrosis in patients with hemophilia type A and B treated with protease inhibitors. A causal relationship has not been established. Phenylketonuria: Nelfinavir powder contains 11.2 mg phenylalanine per gm of powder.


Drug Side Effects ::

 Adverse Reactions

CNS: Headache; paresthesia; dizziness; insomnia; somnolence; anxiety; depression; seizures; emotional lability; hyperkinesis. DERM: Rash; pruritus; sweating; urticaria. EENT: Pharyngitis; rhinitis; sinusitus. GI: Anorexia; diarrhea; dyspepsia; flatulence; nausea; vomiting; abdominal pain; pancreatitis; bleeding; mouth ulcerations. GU: Sexual dysfunction; kidney calculus. HEPA: Hepatitis. HEMA: Anemia; leukopenia; thrombocytopenia. META: Increased alkaline phosphotase; liver function tests; creatinine phosphokinase; hyperlipidemia. RESP: Dyspnea. OTHER: Asthenia; fever; myalgia; back pain; malaise; arthralgia; myasthenia; myopathy.

Drug Mode of Action ::  

 Action Inhibits human immunodeficiency virus (HIV) protease, the enzyme required to form functional proteins in HIV-infected cells.

Drug Interactions ::


Amiodarone, astemizole, cisapride, quinidine, rifabutin, terfenadine: Nelfinavir may elevate blood levels of these drugs, which may increase the risk of arrhythmias or other potential serious adverse effects. Alprazolam, clorazepate, diazepam, estazolam, flurazepam, midazolam, triazolam, zolpidem: Nelfinavir may increase blood levels of these drugs, which may produce extreme sedation and respiratory depression. Do not coadminister. Rifampin: May decrease plasma concentrations of nelfinavir. Oral contraceptives: Concentrations of ethinyl estradiol, a component of oral contraceptives, may be reduced. Indinavir: Nelfinavir may increase indinavir blood levels. Indinavir, retonavir: May increase nelfinavir plasma concentrations. Carbamazepine, phenobarbital, phenytoin: May decrease nelfinavir plasma concentrations.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies. Note hepatic function impairment, phenylketonuria or diabetes.
  • Obtain baseline triglycerides, SGOT, SGPT, GGT, CPK, blood sugar, and uric acid. Monitor periodically during treatment.
  • Monitor HCT, HGB, WBC, and differential. Note any significant change.
  • Monitor patient for diarrhea, the most frequent side effect. This may be treated with otc antidiarrheals such as loperamide.

Drug Storage/Management ::


  • Administer with food.
  • The oral powder may be mixed with a small amount of water, milk, formula, soy formula, soy milk or dietary supplement (eg, Ensure). Use within 6 hr of mixing.
  • Do not mix oral powder with acidic food or juice (eg, orange juice, apple juice, apple sauce) because of bitter taste.
  • Store tablets and powder at room temperature.

Drug Notes ::

 Patient/Family Education

  • Advise patient to take medication exactly as prescribed, including taking each dose with food to increase absorption.
  • Warn patient not to alter dose or discontinue the medication without consulting the health care provider.
  • Advise patient that if a dose is missed, it should be taken as soon as possible and then return to normal dose. However, if a dose is skipped, the patient should not double the next dose.
  • Instruct patient not to take any other medications, including otc medications, without checking with their health care provider. This medication interacts with a wide range of all types of medications.
  • Explain that the patient will be required to have frequent follow-up blood and urine tests during the course of treatment and to keep appointments.
  • Inform patient that this medication is not a cure for HIV infection and that the patient may continue to acquire secondary illnesses associated with the disease.
  • Emphasize to patient, family, and significant others that this medication does not reduce the risk of transmitting HIV to others through sexual contact or blood contamination.
  • Inform patient that diarrhea is the most common adverse effect and that it can usually be controlled by otc antidiarrheals such as loperamide.
  • Inform patient to report serious or bothersome side effects to the health care provider.
  • Explain that the long-term effects of this medication are not known at this time.
  • Inform patients taking oral contraceptives that alternate or additional contraceptive measures should be used during therapy with nelfinavir.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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