Details About Generic Salt ::  Oxycodon

Main Medicine Class:: Narcotic analgesic combination   

(OX-ee-KOE-dohn/ass-cet-ah-MEE-noe-fen)
Percocet
Tablets: 5 mg oxycodone HCl/325 mg acetaminophen, Tablets: 7.5 mg oxycodone HCl/500 mg acetaminophen, Tablets: 10 mg oxycodone HCl/650 mg acetaminophen, Roxicet, Tablets: 5 mg oxycodone HCl/325 mg acetaminophen, Solution, oral: 5 mg oxycodone HCl/325 mg acetaminophen, Roxicet 5/500, Caplets: 5 mg oxycodone/500 mg acetaminophen, Roxilox, Capsules: 5 mg oxycodone HCl/500 mg acetaminophen, Tylox, Capsules: 5 mg oxycodone HCl/500 mg acetaminophen, Endocet, Oxycocet, Percocet-Demi
Class: Narcotic analgesic combination

 

Drugs Class ::

 Action Acetaminophen inhibits synthesis of prostaglandins and peripherally blocks pain impulse generation, whereas, oxycodone binds to opiate receptors in CNS. Combination has synergistic effect on alleviating pain.

Indications for Drugs ::

 Indications Relief of moderate-to-moderately severe pain.

Drug Dose ::

 Route/Dosage

ADULTS: PO 5 mg (1 tablet, caplet, or teaspoonful) q 6 hr prn.

Contraindication ::

 Contraindications Hypersensitivity to acetaminophen, oxycodone or similar compounds.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Special Risk Patients: Use with caution in elderly, debilitated patients and those with hepatic or kidney failure or conditions accompanied by hypoxia or hypercapnia; monitor carefully to avoid decrease in pulmonary ventilation. Also use cautiously in patients sensitive to CNS depressants, postoperatively and in patients with pulmonary disease. Acute Abdominal Conditions: Diagnosis may be obscured; use with caution. Dependence: Can produce drug dependence; has abuse potential. Head Injury: Respiratory depression and elevation of CSF pressure may be exacerbated. Hepatic Impairment: Chronic alcoholics should limit acetaminophen intake to < 2 g/day. Sulfite Sensitivity: Use with caution in patients known to be sensitive, as some products contain bisulfites.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CARDIOVASCULAR: Hypotension; bradycardia; tachycardia. CNS: Lightheadedness; dizziness; weakness; fatigue; sedation; euphoria; dysphoria; nervousness; headache; confusion. DERMATOLOGIC: Pruritus; rash. GI: Nausea; vomiting; constipation; abdominal pain; anorexia; biliary spasm; dry mouth. GU: Urinary retention or hesitancy. RESPIRATORY: Dyspnea; respiratory depression. OTHER: Malaise; tolerance; psychological and physical dependence with chronic use.

Drug Mode of Action ::  

 Action Acetaminophen inhibits synthesis of prostaglandins and peripherally blocks pain impulse generation, whereas, oxycodone binds to opiate receptors in CNS. Combination has synergistic effect on alleviating pain.

Drug Interactions ::

 Interactions

Anesthetics: Additive CNS depression.

Carbamazepine, hydantoins, sulfinpyrazone: Increased risk of hepatotoxicity.

CNS depressants (eg, barbiturates, tricyclic antidepressants, phenothiazines, sedatives, hypnotics, alcohol, other narcotics): Additive CNS depression.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess type, location, and intensity of pain before administration and frequently during treatment.
  • Assess vital signs before administration and periodically during treatment.
  • Assess for signs of narcotic dependence.
  • Assess bowel function routinely. If constipation develops, provide additional fluids, high-fiber foods, or stool softeners.
  • If respiratory depression develops, notify health care provider immediately and prepare emergency equipment.
  • If sedation or confusion develops, take safety precautions (eg, keep side rails up, assist with ambulation).
  • Evaluate patient's continuing need for therapy since psychological and physical dependence and tolerance may develop.
OVERDOSAGE: SIGNS & SYMPTOMS
  Miosis, respiratory depression, CNS depression (somnolence progressing to stupor or coma), hepatic damage, circulatory collapse, cardiopulmonary arrest, death

Drug Storage/Management ::

 Administration/Storage

  • Administer with food or milk to minimize GI irritation.
  • Store at room temperature in tightly-closed container.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to take medication before pain becomes severe for greatest effectiveness.
  • Teach patient methods to prevent constipation.
  • Instruct patient to make position changes slowly if lightheadedness or sedation occurs.
  • Advise patient to avoid intake of alcoholic beverages or products containing alcohol while using this medication.
  • Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.
  • Caution patient that physical dependency and withdrawal symptoms may occur following discontinuation of long-term therapy.
  • Instruct patient not to take any otc medications without consulting health care provider.

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Disclaimer ::

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