Article Contents ::

Details About Generic Salt ::  Pindolol

Main Medicine Class:: Beta-adrenergic blocker   

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

 

Drugs Class ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Indications for Drugs ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Drug Dose ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Contraindication ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Drug Precautions ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Drug Side Effects ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Drug Mode of Action ::  

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Drug Interactions ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Drug Assesment ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Drug Storage/Management ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Drug Notes ::

(PIN-doe-lahl)
Visken,  Alti-Pindolol, APO-Pindol, Gen-Pindolol, Novo-Pindol, Nu-Pindol
Class: Beta-adrenergic blocker

 

Action Nonselectively blocks beta receptors, which primarily affect heart (slows rate), vascular musculature (decreases blood pressure) and lungs (reduces function).

 

Indications Management of mild-to-moderate hypertension.

 

Contraindications Greater than first-degree heart block; CHF unless secondary to tachyarrhythmia treatable with beta-blockers; overt cardiac failure; sinus bradycardia; cardiogenic shock; hypersensitivity to beta-blockers; bronchial asthma or bronchospasm, including severe COPD.

 

Route/Dosage

ADULTS: PO 5 mg bid. May be increased by 10 mg q 3 to 4 wk until desired response; maximum dose is 60 mg/day.

 

Interactions

Clonidine: May enhance or reverse antihypertensive effect; potentially life-threatening situations may occur, especially on withdrawal. Epinephrine: Initial hypertensive episode followed by bradycardia may occur. Ergot alkaloids: Peripheral ischemia, manifested by cold extremities and possible gangrene, may occur. Insulin: Prolonged hypoglycemia with masking of symptoms may occur. Lidocaine: Lidocaine levels may increase, leading to toxicity. Nonsteroidal anti-inflammatory agents: Some agents may impair antihypertensive effect. Prazosin: Orthostatic hypotension may be increased. Theophyllines: Elimination of theophylline may be reduced. Also, effects of both drugs may be reduced by pharmacologic antagonism. Verapamil: Effects of both drugs may be increased.

 

Lab Test Interferences None well documented.

 

Adverse Reactions

CV: Bradycardia; hypotension; congestive heart failure; edema; worsening angina. CNS: Depression; visual disturbances; short-term memory loss; dizziness. DERM: Skin rash; increased sensitivity to cold. EENT: Dry eyes; visual disturbances. GI: Nausea; vomiting; diarrhea. GU: Impotence; urinary retention; difficulty with urination. HEMA: Agranulocytosis. HEPA: May increase AST or ALT; rarely increases LDH or alkaline phosphatase. META: May increase or decrease blood glucose, uric acid. RESP: Wheezing; bronchospasm; difficulty breathing (at higher doses).

 

Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred; aggressive therapy may be required. Diabetics: May mask signs and symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Thyrotoxicosis: May mask clinical signs of developing or continuing hyperthyroidism (eg, tachycardia). Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm. CHF: Administer cautiously in CHF patients controlled by digitalis and diuretics. Notify physician at first sign or symptom of CHF or unexplained respiratory symptoms in any patient.

Renal/Hepatic function impairment: Dosage may need to be reduced.

PATIENT CARE CONSIDERATIONS


 

Administration/Storage

  • Give orally.
  • Give medication at same time each day.
  • May be taken without regard to meals.
  • Store at room temperature and protect from moisture, light, and air.

 

Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess pulse and BP prior to initiation of therapy.
  • Monitor BP, apical, and radial pulses, intake and output, daily weight, respiration, and circulation in extremities.
  • Review baseline serum glucose level, results of liver and renal function studies, and monitor lab data throughout therapy.
  • Monitor blood glucose closely for diabetic patients.
  • Notify physician if symptoms of CHF occur (eg, difficulty breathing, cough, or swelling in extremities).
  • Report bothersome side effects to physician, especially new-onset depression.
  • Reduce dose gradually upon discontinuation of therapy. Abrupt withdrawal is associated with adverse effects, including precipitation, or worsening of angina.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bradycardia, hypotension, seizures, respiratory depression

 

Patient/Family Education

  • Teach patient and family technique for measuring BP and pulse rates and to keep written record.
  • Instruct patient to notify physician if pulse rate is < 50 bpm or systolic BP is < 90 mm Hg.
  • Warn patient not to engage in activities that require mental alertness until drug effects are apparent because it may cause blurred vision, drowsiness, and dizziness.
  • Explain that decreased blood supply to extremities may cause patient to be more sensitive to cold temperatures.
  • Encourage patients with diabetes to monitor blood glucose carefully.
  • Advise patient to report the following symptoms to physician: Any asthma-like symptoms, cough or nasal stuffiness, skin rash, fever, sore throat, unusual bleeding or bruising.
  • Instruct patient not to take any otc medications without consulting physician.
  • Instruct patient to sit or lie down immediately if dizziness or faintness occurs.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

DOWNLOAD OUR ANDROID APP

One of the 1st in India.High Quality Generic Medicine Portal Android Application for Online Oreder & Information.

For More Join Our Membership and Get Additional 25% off on Meds, also get MLM Benefits to get a permanent earning source.

Join Membership How to Search Medicine
Android App

We would like to keep you updated with special notifications.