Details About Generic Salt ::  Ranitid1

Main Medicine Class:: Histamine H2 antagonist,H. Pylori Agent   

(ran-EYE-tih-DEEN BISS-muth)
Tritec
Class: Histamine H2 antagonist/H. Pylori Agent

 

Drugs Class ::

 Action Suppresses gastric acid secretion and bismuth, which may aid in Helicobacter pylori eradication. Used in combination with clarithromycin, a macrolide antibiotic.

Indications for Drugs ::

 Indications Treatment of active duodenal ulcers associated with H. pylori infection when used in combination with clarithromycin. Eradication of this bacterium reduces the risk of ulcer recurrence.

Drug Dose ::

 Route/Dosage

ADULTS: PO 400 mg bid for 28 days in conjunction with clarithromycin (Biaxin) 500 mg tid for the first 14 days.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established Porphyria: Do not use in patients with history of porphyria. Renal function impairment: Not recommended for use in patients with creatinine clearance < 25 ml/min or less. Treatment failure: Patients who fail to respond to therapy should not be retreated with a regimen containing clarithromycin.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CNS: Headache. GI: Diarrhea; constipation; benign dark or black coloration of the tongue or feces.

Drug Mode of Action ::  

 Action Suppresses gastric acid secretion and bismuth, which may aid in Helicobacter pylori eradication. Used in combination with clarithromycin, a macrolide antibiotic.

Drug Interactions ::

 Interactions

Antacids: High doses lower ranitidine and possibly bismuth levels. Clarithromycin: Increased ranitidine and bismuth levels. However, the combination is indicated to eradicate H. pylori and is not likely to be clinically relevant.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history including drug history and any known allergies. Note renal impairment and history of acute porphyria.
  • Monitor CBC, renal and liver function test results.
  • Ensure that clarithromycin is used concurrently during first 14 days of therapy.
  • Monitor the adverse effects and report significant findings to physician.
OVERDOSAGE: SIGNS & SYMPTOMS
  Bismuth: Neurotoxcity, nephrotoxicity.

Drug Storage/Management ::

 Administration/Storage

  • Can be taken with or without food.
  • Administer in combination with antibiotic agent (eg, clarithromycin) for first 14 days of therapy for the treatment of active duodenal ulcer.
  • Refrigerate or store at room temperature. Protect from light in tightly closed container. Protect from moisture.

Drug Notes ::

 Patient/Family Education

  • Instruct the patient to take ranitidine bismuth citrate twice daily as prescribed.
  • Inform patient that in order for therapy to work, clarithromycin must be taken tid for first 14 days of therapy.
  • Instruct patient not to take otc medications without consulting healthcare provider.
  • Instruct the patient not to take an antacid at the same time as this combination therapy. This action may result in a decrease in plasma concentration of both bismuth and ranitidine.
  • Advise patient to complete full course of therapy even if symptoms have resolved.
  • Inform patient of potential adverse effects and precautions associated with separate drugs in this combination therapy
  • Advise patient that bismuth may cause a temporary darkening of the tongue and stool.
  • Instruct patient not to confuse the stool darkening with blood in the stool (melena). Occult blood testing may be necessary.
  • Instruct patient to report any signs of bleeding to primary care provider.
  • Instruct patient to notify primary care provider of any adverse reactions.
  • Instruct female patients to notify primary care provider if they are pregnant or plan to become pregnant.
  • Advise patients not to breastfeed while taking this medication.

Disclaimer ::

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